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. 2021 Feb 12;7:13. doi: 10.1038/s41523-021-00221-z

Table 2.

Correlation between Ki67 labeling indexes/tumor grade and 21-gene recurrence score as categorical variables in women age ≥ 50.

Variable RS category based on TAILORx Total χ2 P value
0–15 16–19 20–25 >25
Ki67 hotspot
 <10 4 4 3 1 12 (13.8%) 24.71 0.016
 <20 12 3 0 0 15 (17.2%)
 <30 14 3 3 2 22 (25.3%)
 <40 6 2 3 5 16 (18.4%)
 ≥40 4 5 7 6 22 (25.3%)
Ki67 average
 <10 27 10 5 2 44 (50.6%) 30.49 0.0023
 <20 12 5 6 6 29 (33.3%)
 <30 1 2 4 2 9 (10.3%)
 <40 0 0 1 3 4 (4.6%)
 ≥40 0 0 0 1 1(1.1%)
Ki67 hottest spot
 <10 3 4 2 1 10 (11.5%) 21.41 0.0447
 <20 8 3 1 0 12 (13.7%)
 <30 15 2 2 2 21 (24.1%)
 <40 9 3 4 3 19 (21.8%)
 ≥40 5 5 7 8 25 (28.7%)
Grade
 1 9 4 0 2 15 (17.2%) 17.80 0.0067
 2 29 13 11 7 60 (69.0%)
 3 2 0 5 5 12 (13.8%)
Grade and Ki67 combined
 Low risk (grade 1 or hotspot < 20) 23 8 3 2 36 (41.4%) 12.13 0.0069
 High risk (others) 17 9 13 12 51 (58.6%)
Total 40 (46.0%) 17 (19.5%) 16 (18.4%) 14 (16.1%) 87