Table 3.
Representative protein-coding genes significantly affected by AS6 in HUMEC and MCF7 cells.
| Involved biological pathways | |
|---|---|
| HUMEC | |
| Upregulated genes | |
| CHEK1, HDAC3, NCOR1, SIRT6, RNF185 | Cellular responses to stresses |
| BUB1B, CDC20, CCNB1, PLK1, POLR2A, DROSHA, ALDOA | Nucleotide and protein catabolic pathways |
| STAT6, PARP3, PPP4C, SUMO1, E2F7, KPNA2, XRCC6, TCF2, SMG1 | Double strand DNA break repair through homologous recombination |
| CDK6, CDK10, KIF14, ENSA, CEP72 | Heme degradation |
| Downregulated genes | |
| MED1, HIF1A, NCOA6 | Organophosphate biosynthetic process |
| ARHGDIA, LPAR1, CDH13, PLD1, OGT, NRG1, CDC42EP3, PDCD10, RAB7B | Ras protein signaling transduction |
| CASP4, CASP9, DDX3X, MUC1, SOD2, URI1, BCLAF1, PDCD10, RRM2B, PRR7, CSK, DAB1, DLG1, INPP5K | Intrinsic apoptotic pathway |
| MCF7 | |
| Upregulated genes | |
| ARF1, FLNA, EXOSC3, CLU, SURF4, VAMP7 | Exocytosis |
| HSPA4, HSP90AA1, BAG2, HSPA1B, HSPA6, HSPA1A | Cellular responses to internal stresses |
| PSMB2, PSMB3, PSMB7, PSMC5, PSMD11, PSMD6, CUL1, USP1, BAG2, USP3, USP16, PARK7, NEDD4L, NUPR1, USP36, UBE2Z, UBR1 | Protein catabolic processes |
| BCLAF1, BCL10 | Autophagy |
| Downregulated pathways | |
| CDK1, CDC25A, CDKN2A, CENPE, CENPF, CENPI, MCM4, MCM7, POLD2, POLE2, AURKA, TOP2A, YWHAH, AURKB, KIF23, PLK4, CHEK2, POLA2, AURKB, CHEK2, E2F8, WEE1 | Cell cycle |
| ATM, ATR, BRCA1, BLM, BRCC3, APEX1, POLK, CRY2, COPS7B, MSH6, KAT5, RECQL, PALB2, RAD9A, RAD21, RAD51, EME1, TP53, DDX11, TP73, MSH2, PARP1, RAD54L, TRIP13, RECQL4, RNASEH2A, RUVL2, TREX1 | DNA repair |
| POLD2, POLE2, RFC1, RFC4, CT3, XRCC3, BLM, H3-3A, MKS1, | Telomere organization |
| BIRC5, BMI1, DDX17, ESR1, H4C1, H4C2, NRIP1, NUP43, SENP2, TDG, TFAP2A, ZBED1 | Sumoylation |