Fig. 6.

Overview of the correspondence between the histology-based multivariate analysis and the NMF analysis for NC- and fibrin-containing areas. A: Bar graphs showing the number of NC VIP values above 1.0 that were allocated to the different NMF component spectra. Most NC VIP values were allocated to NMF component V. B: The results in A are illustrated by depicting the NMF weight images of component V for four tissue sections with superimposed NC segmentation. C: The number of fibrin VIP values above 1.0 allocated to the different NMF component spectra. Most fibrin VIP values were present in NMF component III. D: The NMF weight images of component III with fibrin segmentation for four tissue sections. Scale bars are 1 mm. Sections J-6 and K-9 are also depicted in Figs. 3 and 5. Section I-4 is also depicted in Figs. 1, 3, 4, and 5. MVA, multivariate analysis; NMF, nonnegative matrix factorization.