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. 2021 Jan 27;24(2):102093. doi: 10.1016/j.isci.2021.102093

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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IL-27 signaling is not associated with CD44^hi T cell apoptosis in septic mice

(A) Representative flow cytometric plots showing Caspase 3/7 (x axis) by SSC (y axis) on CD44^hi memory CD4⁺ T cells in wild-type and Il27ra^−/− mice on days 1 and 2 after sham surgery (“sham”) or CLP surgery (left). The frequency of apoptotic (Caspase 3/7⁺) CD44^hi memory CD4⁺ T cells is summarized on the right.

(B) Representative flow cytometric plots showing Caspase 3/7 (x axis) by SSC (y axis) on CD44^hi CD8⁺ T cells after sham or CLP surgery in wild-type and Il27ra^−/− mice on days 1 and 2 after surgery (left). The frequency of apoptotic (Caspase 3/7⁺) CD44^hi memory CD8⁺ T cells is summarized on the right. Data are representative of two experiments with n = 5–9 mice per group. Error bars represent the mean ± the standard deviation.