Table 1.

Cell lines study and animal models used for Safranal study and their implication.

S.No.	Year	Cell Line Study/Animal Model	Disease/Disorder	Ref.
1	2004	DMBA Induced model	Carcinogenesis	(Das et al., 2004)
2	2006	Methacholine mouse model	Asthma	(Boskabady et al., 2006)
3	2014	Neuroblastoma cells	Cancer	(Farahzad et al., 2014)
4	2013	Endothelin 1 mouse model	Inflammation	(Gholamnezhad et al., 2013)
5	2013	Isoproterenol mouse model	Cardiovascular diseases	(Mehdizadeh et al., 2013)
6	2013	HeLa, MCF7 and L929 cell lines	Cancer	(Malaekeh-Nikouei et al., 2013)
7	2013	Acetic acid mouse model	Inflammation	(Tamaddonfard et al., 2013)
8	2014	Ovalbumin sensitized model	Asthma	(Boskabady et al., 2014)
9	2014	Mouse myoblast cell line (C2C12)	Type 2 Diabetes Mellitus	(Maeda et al., 2014)
10	2014	KK-Ay/Kwl (KK-Ay)	Type 2 Diabetes Mellitus	(Maeda et al., 2014)
11	2014	MTT mouse model	Lung cancer	(Farahzad et al., 2014)
12	2015	P23H	Retinitis pigmentosa	(Fernández-sánchez et al., 2015)
13	2015	DOCA mouse model	Hypertension	(Imenshahidi et al., 2015)
14	2016	Phenylephrine mouse model	Hypertension	(Razavi et al., 2016)
15	2016	Peripheral blood mononuclear cells	Inflammation	(Feyzi et al., 2016)
16	2017	HeLa cell	Cancer	(Cheriyamundath et al., 2017)
17	2017	KB and NIH 3T3 cell lines	Oral squamous cell carcinoma	(Jabini et al., 2017)
18	2018	Neural Stem Cells (NSC)	Parkinson's Disease	(Zhao and Xi, 2018)
19	2018	Streptozocin mouse model	Diabetes	(Delkhosh-kasmaie et al., 2018)
20	2018	HepG2 Cell Lines	Liver Cancer	(Al-hrout et al., 2018)
21	2019	PC12 Cells	Alzheimer Disease	(Rafieipour et al., 2019)