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. 2021 Feb 12;11:3747. doi: 10.1038/s41598-021-83296-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Orco CBS mutation on the sensitization in Or22a/Orco expressing OSNs. (a) Time course of Ca²⁺ fluorescence response (∆F/F₀ (%)) in OrcoWT OSNs upon OR stimulation with 0.05 µM ethyl hexanoate (n = 14). (b) Intensity of 1st and 2nd Ca²⁺ fluorescence responses (∆F/F₀ (%)) for OrcoWT OSNs. (c) Time course of Ca²⁺ fluorescence response (∆F/F₀ (%)) in OrcoK339N OSNs upon OR stimulation with 0.5 µM ethyl hexanoate (n = 12). (d) Intensity of 1st and 2nd Ca²⁺ fluorescence responses (∆F/F₀ (%)) for OrcoK339N OSNs. Intensity of 1st and 2nd response was calculated by subtracting the base level from the maximum Ca²⁺fluorescence. In case of sensitization, the 2nd response is significantly higher than 1st response. n = cell bodies. Two-tailed paired t-test, *P < 0.05, ***P < 0.001. Data given as mean ± SEM.