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. 2021 Feb 12;5:6. doi: 10.1038/s41698-021-00151-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–l phylogenetic tree of BM38, BM39, BM35, BM43, BM42, BM36, BM40, BM31, BM33, BM32, BM34, and BM37. For each panel, heatplot with different bars represents various distributions of identified mutations including somatic SNVs and CNVs. Fraction of ubiquitous identified mutations (trunk) and unique identified mutations (branch) reveal the phylogenetic relationship of BM_P and BM_M within a single case. BM_P primary lesion, BM_M brain metastatic lesion.