Table 1.
Detected miRNA Target Genes and Signaling Pathways
| KEGG Pathways Enrichment in Target Genes | Target Genes |
|---|---|
| miR-410 has potential effects on 805 predicted target genes and is found in 173 signaling pathways, in which miR-410 is involved in retinal physiology/pathology | |
| Retinol metabolism | ALDH1A2 |
| Apoptosis | NTRK1, IL1R1, PRKAR2B, PPP3CA, BIRC4 |
| Nicotinate and nicotinamide metabolism | PBEF1 |
| VEGF signaling pathway | KRAS, MAPK1, PPP3CA |
| Complement and coagulation cascades | CD55, PLAU |
| miR-19a has potential effects on 839 predicted target genes and is found in 166 signaling pathways, in which miR-19a is involved in retinal physiology/ pathology | |
| VEGF signaling pathway | PIK3CA, NFATC2, KRAS, SPHK2, PLA2G10, MAPK14, PIK3R3, RAF1 |
| Apoptosis | PIK3CA, IL1R1, MAP3K14, PRKACB, PIK3R3 |
| Complement and coagulation cascades | CR2, F3 |
| miR-126 has potential effects on 22 predicted target genes and is found in 6 signaling pathways, in which miR-126 is involved in retinal physiology/pathology | |
| Cell communication | ITGA6 |