. 2021 Feb 10;10(2):12. doi: 10.1167/tvst.10.2.12

Table 2.

Expression of miRNAs (That Regulate Apoptosis) From ARPE19 Cells After Exposure to Exosomes Extracted From Serum of Patients With “Wet” or “Dry” AMD

					Upregulation or
	Fold Change		P Value		Downregulation
Mature ID	Wet	Dry	Wet	Dry	Wet	Dry
let-7a-5p	1.27	8.08^*	0.5218	0.0256^*	1.27	8.08^*
let-7c	1.59	3.19^*	0.1130	0.0267^*	1.59	3.19^*
let-7e-5p	2.01^*	4.04^*	0.0854	0.0199^*	2.01^*	4.04^*
let-7g-5p	1.27	6.34^*	0.5120	0.0000^*	1.27	6.34^*
hsa-miR-1	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-101-3p	0.20^**	0.50	0.0001^*	0.0000^*	–4.93^**	–1.99
miR-106b-5p	1.59	6.42^*	0.3481	0.0000^*	1.59	6.42^*
miR-122-5p	0.20^**	0.50	0.0000	0.0000^*	–4.99^**	–1.99
miR-125a-5p	0.80	5.08^*	0.4660	0.0000^*	–1.25	5.08^*
miR-125b-5p	2.53^*	6.42^*	0.0572	0.0000^*	2.53^*	6.42^*
miR-128	0.34^**	1.71	0.0123	0.0929	–2.96^**	1.71
miR-1285-3p	10.62^*	4.17^*	0.1415	0.0828	10.62^*	4.17^*
miR-133a	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-133b	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-134	0.34^**	0.52	0.0021^*	0.0000^*	–2.93^**	–1.91
miR-141-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-143-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-144-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-145-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-146a-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-149-3p	1.67	8.35^*	0.0976	0.0771	1.67	8.35^*
miR-153	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-15a-5p	0.21^**	0.67	0.0001^*	0.1709	–4.83^**	–1.50
miR-15b-5p	2.53^*	5.07^*	0.0547	0.0197^*	2.53	5.07^*
miR-16-5p	1.26	6.37^*	0.7873	0.0172^*	1.26	6.37^*
miR-17-5p	2.54^*	10.08^*	0.0531	0.0113^*	2.54^*	10.08^*
miR-181a-5p	2.55^*	5.07^*	0.2578	0.0040^*	2.55^*	5.07^*
miR-181b-5p	2.52^*	5.03^*	0.0546	0.0185^*	2.52^*	5.03^*
miR-181c-5p	4.15^*	8.23^*	0.2340	0.0054^*	4.15^*	8.23^*
miR-181d	1.29	3.24^*	0.3539	0.0252^*	1.29	3.24^*
miR-183-5p	0.43^**	1.34	0.0035^*	0.3018	–2.35^**	1.34
miR-185-5p	0.43^**	1.07	0.0035^*	0.0013^*	–2.35^**	1.07
miR-186-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-192-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99	–1.99
miR-193a-5p	1.01	1.26	0.9728	0.3771	1.01	1.26
miR-193b-3p	4.02^*	5.05^*	0.0476^*	0.0040^*	4.02^*	5.05^*
miR-194-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99	–1.99
miR-195-5p	2.03^*	10.19^*	0.0838	0.0000^*	2.0^*3	10.19^*
miR-200c-3p	0.21^**	0.51	0.0001^*	0.0000^*	–4.73^**	–1.95
miR-203a	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-204-5p	0.26^**	0.54	0.0045^*	0.0000^*	–3.83^**	–1.87
miR-205-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-206	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-20a-5p	2.53^*	6.42^*	0.0541	0.0000^*	2.53^*	6.42^*
miR-21-5p	1.59	4.02^*	0.1125	0.0000^*	1.59	4.02^*
miR-210	1.30	2.58^*	0.8002	0.1193	1.30	2.58^*
miR-212-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-214-3p	0.21^**	0.50	0.0001^*	0.0000^*	–4.73^**	–1.99
miR-218-5p	0.20^**	0.51	0.0000^*	0.0000^*	–4.99^**	–1.95
miR-221-3p	1.61	6.40^*	0.1067	0.0134^*	1.61	6.40^*
miR-222-3p	3.21^*	8.07^*	0.0521	0.0001^*	3.21^*	8.07^*
miR-23a-3p	2.02^*	10.18^*	0.0820	0.0000^*	2.02^*	10.18^*
miR-24-3p	2.57^*	8.10^*	0.0526	0.0243^*	2.57^*	8.10^*
miR-25-3p	2.54^*	6.41^*	0.0525	0.0000^*	2.54^*	6.41^*
miR-26a-5p	1.60	8.02^*	0.1098	0.0000^*	1.60	8.02^*
miR-26b-5p	3.19^*	10.11^*	0.1382	0.0117^*	3.19^*	10.11^*
miR-27a-3p	1.60	4.02^*	0.2422	0.0227^*	1.60	4.02^*
miR-29a-3p	2.03^*	6.42^*	0.1423	0.0000^*	2.03	6.42^*
miR-29b-3p	0.27^**	0.54	0.0047^*	0.0000^*	–3.68^**	–1.86
miR-29c-3p	2.03^*	5.08^*	0.0838	0.0000^*	2.03	5.08^*
miR-30a-5p	1.60	8.05^*	0.1103	0.0000^*	1.60	8.05^*
miR-30b-5p	1.31	6.53^*	0.4813	0.0000^*	1.31	6.53^*
miR-30c-5p	3.21^*	12.78^*	0.0242^*	0.0101^*	3.21	12.78^*
miR-30d-5p	1.27	6.35^*	0.5163	0.0000^*	1.27	6.35^*
miR-30e-5p	2.54^*	6.42^*	0.0527	0.0000^*	2.54^*	6.42^*
miR-31-5p	2.03^*	5.10^*	0.0844	0.0000^*	2.03^*	5.10^*
miR-32-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-338-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-34a-5p	1.61	4.01^*	0.1049	0.0000^*	1.61	4.01^*
miR-34c-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-365b-3p	1.64	8.22^*	0.1040	0.0000^*	1.64	8.22^*
miR-378a-3p	0.27^**	0.84	0.0000^*	0.5595	–3.76^**	–1.19
miR-409-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-449a	0.34^**	0.68	0.0111^*	0.1807	–2.96^**	–1.48
miR-451a	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-491-5p	0.20^**	0.50	0.0001^*	0.0000^*	–4.93^**	–1.99
miR-497-5p	0.20^**	0.50	0.0001^*	0.0000^*	–4.92^**	–1.99
miR-512-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-542-3p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-7-5p	0.21^**	0.54	0.0001^*	0.0000^*	–4.70^**	–1.87
miR-708-5p	0.53	1.68	0.0000^*	0.0988	–1.88	1.68
miR-9-5p	0.20^**	0.50	0.0000^*	0.0000^*	–4.99^**	–1.99
miR-92a-3p	1.26	3.19^*	0.5203	0.0014^*	1.26	3.19^*
miR-98-5p	0.43^**	2.70^*	0.0037^*	0.0603	-2.33^**	2.70^*

Fold change values, P value and fold regulation are compared with control.

Fold-change and fold-regulation values of >2 are indicated. P < 0.05.

^**

Fold-change values of <0.5 and fold-regulation values less than –2.