Table 2.
Enriched pathways by the shared proteins between AD and diabetes. The results were extracted from 3 databases: KEGG, WikiPathways, and Reactome databases
| Ontology source | GOTerm | Adjusted P-value | Associated genes |
|---|---|---|---|
| KEGG | Adipocytokine signaling pathway | 1.13778E-11 | ADIPOQ, LEP, LEPR, NPY, PCK1, PPARA, PPARGC1A, SLC2A4, TNF |
| Advanced glycation end products(AGE)-receptor of AGE(RAGE) signaling pathway in diabetes complications | 7.53638E-12 | BAX, BCL2, CASP3, IL-1B, IL-6, NOS3, PIK3R1, TGFB1, TNF, VEGFA | |
| AMP-activated protein kinase (AMPK) signaling pathway | 1.11028E-12 | ADIPOQ, IGF1, INSR, LEP, LEPR, PCK1, PIK3R1, PPARG, PPARGC1A, SIRT1, SLC2A4 | |
| Amyotrophic lateral sclerosis (ALS) | 5.99784E-06 | BAX, BCL2, CASP3, CAT, TNF | |
| Apoptosis | 1.78131E-06 | BAX, BCL2, CASP3, FAS, NGF, PIK3R1, TNF | |
| Fluid shear stress and atherosclerosis | 1.94221E-10 | BCL2, CAV1, CYBA, HMOX1, IL-1B, NOS3, NQO1, PIK3R1, TNF, VEGFA | |
| FoxO signaling pathway | 1.09653E-10 | CAT, IGF1, IL-6, INSR, PCK1, PIK3R1, SIRT1, SLC2A4, SOD2, TGFB1 | |
| Hypoxia-inducible factor 1(HIF-1) signaling pathway | 2.35735E-08 | BCL2, HMOX1, IGF1, IL-6, INSR, NOS3, PIK3R1, VEGFA | |
| Hypertrophic cardiomyopathy (HCM) | 2.93532E-05 | ACE, IGF1, IL-6, TGFB1, TNF | |
| Insulin resistance | 6.54836E-10 | IL-6, INSR, NOS3, PCK1, PIK3R1, PPARA, PPARGC1A, SLC2A4, TNF | |
| Longevity regulating pathway | 2.31646E-12 | ADIPOQ, BAX, CAT, IGF1, INSR, PIK3R1, PPARG, PPARGC1A, SIRT1, SOD2 | |
| Non-alcoholic fatty liver disease (NAFLD) | 7.09E-15 | ADIPOQ, BAX, CASP3, FAS, IL1B, IL-6, INSR, LEP, LEPR, PIK3R1, PPARA, TGFB1, TNF | |
| p53 signaling pathway | 1.3591E-05 | BAX, BCL2, CASP3, FAS, IGF1 | |
| TNF signaling pathway | 6.98289E-06 | CASP3, FAS, IL-1B, IL-6, PIK3R1, TNF | |
| Type II diabetes mellitus | 2.81374E-06 | ADIPOQ, INSR, PIK3R1, SLC2A4, TNF | |
| Reactome | FOXO-mediated transcription | 2.09583E-08 | CAT, CAV1, NPY, PCK1, PPARGC1A, SIRT1, SOD2 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.15153E-07 | CAT, NPY, PCK1, PPARGC1A, SOD2 | |
| Interleukin 4(IL-4) and interleukin 13(IL-13) signaling | 2.25725E-08 | BCL2, HMOX1, IL-1B, IL-6, PIK3R1, TGFB1, TNF, VEGFA | |
| Transcriptional regulation of white adipocyte differentiation | 6.99501E-11 | ADIPOQ, LEP, PCK1, PPARA, PPARG, PPARGC1A, SLC2A4, TGFB1, TNF | |
| VEGFA-VEGF receptor 2(VEGFR2) pathway | 9.37356E-06 | CAV1, CYBA, NOS3, PIK3R1, VEGFA | |
| WikiPathways | Adipogenesis | 6.4079E-14 | ADIPOQ, FAS, IGF1, IL-6, LEP, PCK1, PPARA, PPARG, PPARGC1A, SLC2A4, TGFB1, TNF |
| AMPK signaling | 8.09075E-07 | ADIPOQ, INSR, LEP, LEPR, PIK3R1, SLC2A4 | |
| ALS | 1.34735E-06 | BAX, BCL2, CASP3, CAT, TNF | |
| Apoptosis | 1.32024E-07 | BAX, BCL2, CASP3, FAS, IGF1, PIK3R1, TNF | |
| Folate metabolism | 4.39784E-08 | CAT, IL-1B, IL-6, INSR, MPO, SOD2, TNF | |
| Genes involved in male infertility | 1.61695E-08 | ABCB1, BCL2, CAT, FAS, INSR, NOS3, NQO1, SOD2, TNF | |
| Hepatitis B infection | 2.8804E-07 | BAX, BCL2, CASP3, FAS, IL-6, PIK3R1, TGFB1, TNF | |
| Leptin signaling pathway | 1.30077E-06 | BAX, IL-1B, LEP, LEPR, NOS3, PIK3R1 | |
| NAFLD | 1.7843E-14 | ADIPOQ, BAX, CASP3, FAS, IL-1B, IL-6, INSR, LEP, LEPR, PIK3R1, PPARA, TGFB1, TNF | |
| Photodynamic therapy-induced activator protein 1(AP-1) survival signaling | 4.08953E-06 | BAX, BCL2, FAS, IL-6, TNF | |
| T-Cell antigen receptor (TCR) signaling pathway | 2.47953E-05 | FAS, IL-1B, IL-6, PIK3R1, TGFB1 | |
| TNF alpha signaling pathway | 1.45408E-05 | BAX, CASP3, CYBA, IL-6, TNF | |
| Transcription factor regulation in adipogenesis | 3.4134E-14 | ADIPOQ, IL-6, INSR, LEP, PPARG, PPARGC1A, SLC2A4, TNF | |
| Vitamin B12 metabolism | 2.19331E-07 | IL-1B, IL-6, INSR, MPO, SOD2, TNF |