Table 1.

Critical central nodes are presented. Descriptions are obtained from STRING database and summarized. K, BC, and CC correspond to degree, betweenness centrality, and closeness centrality respectively

R	Gene	K		BC	CC	Stress	description
1	HNRNPA1	23		0.045	0.510	4256	Heterogeneous nuclear ribonucleoprotein A1 involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and possibly modulating splice site selection, and binding to specific miRNA hairpins.
2	JAK2	23		0.012	0.518	1494	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in processes such as cell cycle, cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Is involved in cytokine-driven activation of FOS transcription. Plays a key role in chromatin in the nucleus.
3	PTK2	19		0.004	0.495	534	Protein phosphatase 1 regulatory subunit 71; plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts
4	WT1	15		0.008	0.478	1086	Wilms tumor protein; Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for the development of the urogenital system. Has a tumor suppressor as well as an oncogenic role in tumor formation.
5	B2M	14		0.009	0.500	742	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds to B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.