Table 1.
The top 20 nodes based on degree value and betweenness centrality were selected as hub and bottleneck nodes with differential expression in CD blood and intestine compared to control. CXCL11, GZMB, IL-15, IL-17A, IL-23A, TBX21, and TNFAIP3 had common expression in CD blood and intestinal tissue
| Hub& bottleneck | Degree | Betweenness centrality | Expression | ||
|---|---|---|---|---|---|
| Intestine | Blood | ||||
| 1 | APOA1 | 40 | 0.00634588 | Down (20, 21) | - |
| 2 | CCNA2 | 30 | 0.00841483 | Down (30) | - |
| 3 | CD28 | 63 | 0.00839965 | Up (23) | - |
| 4 | CTLA4 | 88 | 0.02961893 | Up (19) | - |
| 5 | CXCL11 | 45 | 0.02059243 | Up (19(31)) | Up (32) |
| 6 | GZMB | 57 | 0.01230656 | Up (19) | Up |
| 7 | HIF1A | 35 | 0.00923055 | Up (27) | - |
| 8 | HLA-A | 40 | 0.00915393 | Up (30) | - |
| 9 | IL-15 | 67 | 0.01475644 | Up (19) | Up (33) |
| 10 | IL-17A | 86 | 0.01610106 | Up (19) | Up (28, 34) |
| 11 | IL-1B | 95 | 0.01405327 | Up (19) | - |
| 12 | IL-23A | 35 | 0.0535164 | Up (21) | Up (35) |
| 13 | IL-2RB | 53 | 0.00721186 | Up (14) | - |
| 14 | IRAK1 | 32 | 0.00518941 | Down (18) | - |
| 15 | ITGA4 | 32 | 0.03352843 | Down (18) | - |
| 16 | MKI67 | 32 | 0.01219633 | Up (19) | - |
| 17 | STAT3 | 115 | 0.00616552 | Up (21) | - |
| 18 | TBX21 | 55 | 0.02993936 | Up (19) | Up (28, 34) |
| 19 | TNFAIP3 | 35 | 0.00532498 | Up (22) | Up (23) |
| 20 | TYROBP | 40 | 0.0078105 | Up (19) | - |