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. 2020 Winter;13(Suppl1):S60–S67.

Table 2.

Biological process of the genes as hub-bottleneck nodes

Associated genes GOTerm
[CTLA4, TNFAIP3, TYROBP] Negative regulation of B cell activation
[APOA1, IL-15, IL-1B, IL-2RB] Positive regulation of phagocytosis
[IL-15, IL-2RB, STAT3] Response to IL-15
IL-15-mediated signaling pathway
Cellular response to IL-15
[CD28, IL-23A, TYROBP] Production of IL-10
Regulation of IL-10 production
Production of IL-10
Regulation of IL-10 production
[CD28, IL-1B, STAT3, TYROBP] Positive regulation of cytokine biosynthetic process
[IL-1B, STAT3, TYROBP] IL-6 biosynthetic process
Regulation of IL-6 biosynthetic process
Positive regulation of IL-6 biosynthetic process
[IL-23A, STAT3, TBX21] CD4-positive, alpha-beta T cell differentiation involved in immune response
T-helper cell lineage commitment
T-helper 17 cell differentiation
T-helper 17 type immune response
T-helper 17 cell lineage commitment
Activation of alpha-beta T cell involved in immune response
[CD28, IL-1B, TBX21, TNFAIP3] Production of IL-2
[HLA-A, IL-23A, TYROBP] Positive regulation of leukocyte-mediated cytotoxicity
[CD28, IL-23A, TYROBP]
[CD28, IL-1B, TBX21, TNFAIP3] Regulation of IL-2 production
[HLA-A, IL-1B, TBX21] T cell cytokine production
Regulation of T cell cytokine production
[CD28, HLA-A, IL-1B, IL-23A, TBX21]
[IL-15, IL-1B, IL-23A, TNFAIP3] Regulation of defense response to virus
Regulation of defense response to virus by host
[CD28, HLA-A, IL-1B, IL-23A, TBX21] Positive regulation of adaptive immune response
Positive regulation of lymphocyte-mediated immunity
Positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
[IL-15, IL-23A, TYROBP] Regulation of natural killer cell activation
Positive regulation of natural killer cell activation
[CD28, IL-1B, STAT3, TYROBP] Positive regulation of cytokine biosynthetic process
[HLA-A, IL-1B, IL-23A, TBX21] Regulation of T cell-mediated immunity
[CD28, HLA-A, IL-15, IL-23A] Proliferation of alpha-beta T cell
[HLA-A, IL-1B, IL-23A] Positive regulation of T cell-mediated immunity
[CD28, IL-15, IL-23A, STAT3, TBX21] T cell selection
[IL-23A, STAT3, TBX21] T cell lineage commitment
[CD28, HLA-A, IL-23A] Regulation of alpha-beta T cell proliferation
[IL-23A, STAT3, TBX21] Positive T cell selection
Lineage commitment of alpha-beta T cell
Lineage commitment of CD4-positive or CD8-positive, and alpha-beta T cell
[CD28, HLA-A, IL-23A] Positive regulation of alpha-beta T cell proliferation
[IL-17A, IL-23A, TYROBP] Positive regulation of osteoclast differentiation
[IL-23A, STAT3, TBX21] Differentiation of alpha-beta T cell involved in immune response of CD4-positive, alpha-beta T cell lineage commitment