Table 2.
Biological process of the genes as hub-bottleneck nodes
| Associated genes | GOTerm |
|---|---|
| [CTLA4, TNFAIP3, TYROBP] | Negative regulation of B cell activation |
| [APOA1, IL-15, IL-1B, IL-2RB] | Positive regulation of phagocytosis |
| [IL-15, IL-2RB, STAT3] | Response to IL-15 IL-15-mediated signaling pathway Cellular response to IL-15 |
| [CD28, IL-23A, TYROBP] | Production of IL-10 Regulation of IL-10 production Production of IL-10 Regulation of IL-10 production |
| [CD28, IL-1B, STAT3, TYROBP] | Positive regulation of cytokine biosynthetic process |
| [IL-1B, STAT3, TYROBP] | IL-6 biosynthetic process Regulation of IL-6 biosynthetic process Positive regulation of IL-6 biosynthetic process |
| [IL-23A, STAT3, TBX21] | CD4-positive, alpha-beta T cell differentiation involved in immune response T-helper cell lineage commitment T-helper 17 cell differentiation T-helper 17 type immune response T-helper 17 cell lineage commitment Activation of alpha-beta T cell involved in immune response |
| [CD28, IL-1B, TBX21, TNFAIP3] | Production of IL-2 |
| [HLA-A, IL-23A, TYROBP] | Positive regulation of leukocyte-mediated cytotoxicity |
| [CD28, IL-23A, TYROBP] | |
| [CD28, IL-1B, TBX21, TNFAIP3] | Regulation of IL-2 production |
| [HLA-A, IL-1B, TBX21] | T cell cytokine production Regulation of T cell cytokine production |
| [CD28, HLA-A, IL-1B, IL-23A, TBX21] | |
| [IL-15, IL-1B, IL-23A, TNFAIP3] | Regulation of defense response to virus Regulation of defense response to virus by host |
| [CD28, HLA-A, IL-1B, IL-23A, TBX21] | Positive regulation of adaptive immune response Positive regulation of lymphocyte-mediated immunity Positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| [IL-15, IL-23A, TYROBP] | Regulation of natural killer cell activation Positive regulation of natural killer cell activation |
| [CD28, IL-1B, STAT3, TYROBP] | Positive regulation of cytokine biosynthetic process |
| [HLA-A, IL-1B, IL-23A, TBX21] | Regulation of T cell-mediated immunity |
| [CD28, HLA-A, IL-15, IL-23A] | Proliferation of alpha-beta T cell |
| [HLA-A, IL-1B, IL-23A] | Positive regulation of T cell-mediated immunity |
| [CD28, IL-15, IL-23A, STAT3, TBX21] | T cell selection |
| [IL-23A, STAT3, TBX21] | T cell lineage commitment |
| [CD28, HLA-A, IL-23A] | Regulation of alpha-beta T cell proliferation |
| [IL-23A, STAT3, TBX21] | Positive T cell selection Lineage commitment of alpha-beta T cell Lineage commitment of CD4-positive or CD8-positive, and alpha-beta T cell |
| [CD28, HLA-A, IL-23A] | Positive regulation of alpha-beta T cell proliferation |
| [IL-17A, IL-23A, TYROBP] | Positive regulation of osteoclast differentiation |
| [IL-23A, STAT3, TBX21] | Differentiation of alpha-beta T cell involved in immune response of CD4-positive, alpha-beta T cell lineage commitment |