Table 3.
The enriched pathways from KEGG related to 20 central nodes of CD network
| Associated genes | GOTerm |
|---|---|
| [CD28, IL-15, ITGA4] | Intestinal immune network for IgA production |
| [IL-1B, IRAK1, ITGA4] | Leishmaniasis |
| [CD28, IL-1B, IL-2RB, IRAK1, STAT3, TNFAIP3] | Measles |
| [CD28, CTLA4, IL-15, IL-17A, IL-1B, IL-23A] | Rheumatoid arthritis |
| [HIF1A, IL-17A, IL-1B, IL-23A, IL-2RB, STAT3, TBX21] | Differentiation of Th17 cell |
| [IL-17A, IL-1B, IL-23A, STAT3, TBX21] | Inflammatory bowel disease (IBD) |
| [CD28, GZMB, HLA-A, IL-1B] | Type I diabetes mellitus Graft-versus-host disease |
| [CD28, CTLA4, GZMB, HLA-A] | Autoimmune thyroid disease |
| [CD28, GZMB, HLA-A] | Allograft rejection |