TABLE 2.
Dementia risk (HR (95% CI)) for BMI, waist circumference, and fat mass (men and women)
| Men (HR (95%CI)) |
Women (HR(95%CI)) |
|||||
|---|---|---|---|---|---|---|
| Range | Model 1 | Model 2 | Range | Model 1 | Model 2 | |
| BMI (kg/m2) | ||||||
| 1st Quartilea | 18.72–23.69 | 1 | 1 | 17.52–23.40 | 1 | 1 |
| 2nd Quartile | 23.79–25.99 | 0.78 (0.44,1.40) | 0.56(0.27,1.14) | 23.45–26.38 | 0.88 (0.55,1.39) | 0.91 (0.54,1.52) |
| 3rd Quartile | 26.04–28.29 | 0.38 (0.19,0.76) | 0.28 (0.11,0.71) | 26.44–29.64 | 0.94 (0.59,1.50) | 0.87 (0.46,1.63) |
| 4th Quartile | 28.62–34.27 | 0.59(0.29,1.19) | 0.35 (0.12,1.02) | 29.64–41.15 | 1.04 (0.65,1.67) | 0.92 (0.48,1.76) |
| P-trend | .03 | .03 | .81 | .77 | ||
| Waist circumference/height2 (m/m2) | ||||||
| 1st Quartile | 0.23–0.30 | 1 | 1 | 0.24–0.34 | 1 | 1 |
| 2nd Quartile | 0.30–0.32 | 1.25 (0.68, 2.29) | 1.27 (0.60, 2.70) | 0.34–0.37 | 1.16 (0.73,1.83) | 1.12 (0.69,1.85) |
| 3rd Quartile | 0.32–0.35 | 0.79 (0.38,1.62) | 0.85 (0.36, 2.00) | 0.38–0.42 | 1.03 (0.65,1.62) | 0.93 (0.54,1.60) |
| 4th Quartile | 0.35–0.42 | 0.79 (0.38,1.65) | 0.70(0.22, 2.22) | 0.42–0.57 | 0.90 (0.56,1.44) | 0.67 (0.38,1.20) |
| P-trend | .29 | .42 | .55 | .14 | ||
| Total fat mass/height2 (kg/m2) | ||||||
| 1st Quartile | 2.24–5.93 | 1 | 1 | 2.37–8.82 | 1 | 1 |
| 2nd Quartile | 5.97–7.32 | 1.05 (0.56,1.96) | 0.77(0.28, 2.10) | 8.83–11.50 | 0.97 (0.61,1.54) | 1.00 (0.59,1.67) |
| 3rd Quartile | 7.32–8.82 | 0.73 (0.39,1.36) | 1.11(0.48, 2.58) | 11.50–13.81 | 0.85 (0.53,1.39) | 0.68 (0.37,1.27) |
| 4th Quartile | 8.85–14.00 | 0.61 (0.29,1.29) | 0.66(0.21, 2.12) | 13.87–24.17 | 0.84 (0.52,1.36) | 0.67 (0.37,1.22) |
| P-trend | .11 | .73 | .41 | .12 | ||
| Trunkfat mass/height2 (kg/m2) | ||||||
| 1st Quartile | 0.61–2.81 | 1 | 1 | 0.59–3.89 | 1 | 1 |
| 2nd Quartile | 2.82–3.79 | 0.82 (0.43,1.55) | 0.85 (0.38,1.94) | 3.91–5.24 | 1.19 (0.76,1.89) | 1.46 (0.89, 2.38) |
| 3rd Quartile | 3.80–4.58 | 0.57 (0.30,1.09) | 0.71 (0.32,1.58) | 5.25–6.41 | 0.99 (0.60,1.61) | 0.94 (0.50,1.78) |
| 4th Quartile | 4.68–8.97 | 0.52 (0.25,1.08) | 0.69 (0.24, 2.01) | 6.42–10.68 | 0.92 (0.57,1.49) | 0.72 (0.37,1.39) |
| P-trend | .04 | .37 | .55 | .26 | ||
| Appendicularfat mass/height2 (kg/m2) | ||||||
| 1st Quartile | 1.37–2.63 | 1 | 1 | 1.43–4.65 | 1 | 1 |
| 2nd Quartile | 2.64–3.20 | 0.67(0.35,1.27) | 0.46 (0.18,1.20) | 4.68–5.86 | 0.88 (0.56,1.38) | 0.68 (0.41,1.13) |
| 3rd Quartile | 3.21–4.00 | 0.87 (0.48,1.57) | 0.94 (0.44, 2.03) | 5.86–7.10 | 0.87 (0.54,1.39) | 0.64 (0.36,1.15) |
| 4th Quartile | 4.01–6.44 | 0.55(0.27,1.12) | 0.72 (0.27,1.89) | 7.10–13.23 | 0.83(0.51,1.36) | 0.66(0.37,1.15) |
| P-trend | .17 | .85 | .48 | .17 | ||
BMI, body mass index; CI, confidence interval; HR, hazard ratio.
Quartiles were defined using all the participants in this analysis. From the lowest to the highest, there are four quartiles (1st quartile: 0–25th percentile, 2nd quartile: 25th–50th percentile, 3rd quartile: 50th–75th percentile, 4th quartile: 75th–100th percentile).
Model 1: age (year) + race (black vs white).
Model 2: age (year) + race (black vs white) + education (≥ 12 years vs <12 years) + APOE ε4 (carrier vs noncarrier) + diabetes (yes vs no) + hypertension (yes vs no) + physical activity (kcal/week) + triglycerides (mmol/L) + current smoking status (yes vs no) + alcohol consumption (drinks/week) + depression scale (point) + TIA/stroke history (yes vs no) + cancer history (yes vs no) + diagnosis of COPD (yes vs no).