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. Author manuscript; available in PMC: 2021 Feb 13.
Published in final edited form as: Alzheimers Dement. 2020 Aug 17;16(10):1402–1411. doi: 10.1002/alz.12125

TABLE 3.

Dementia risk (HR (95% CI)) for lean mass and grip strength (men and women)

Men (HR (95%CI))
Women (HR(95%CI))
Range Model 1 Model 2 Range Model 1 Model 2
Total lean mass/height2 (kg/m2)
 1st Quartile 13.99–16.97 1 1 11.09–13.70 1 1
 2nd Quartile 16.99–18.34 0.76 (0.41,1.41) 0.48 (0.19,1.17) 13.71–14.71 1.21 (0.75,1.94) 1.10 (0.63,1.93)
 3rd Quartile 18.35–19.53 0.67 (0.34,1.29) 0.75 (0.33,1.73) 14.71–15.79 0.98 (0.60,1.61) 0.88 (0.48,1.61)
 4th Quartile 19.62–22.84 0.52 (0.26,1.06) 0.32 (0.13,0.76) 15.82–19.44 1.32 (0.81,2.15) 1.20 (0.66, 2.17)
P-trend .06 .03 .42 .75
Trunk lean mass/height (kg/m2)
 1st Quartile 6.90–8.47 1 1 6.01–7.08 1 1
 2nd Quartile 8.49–9.08 1.60 (0.85,3.00) 1.00 (0.46, 2.20) 7.08–7.54 0.98 (0.60,1.60) 0.68 (0.38,1.19)
 3rd Quartile 9.10–9.73 1.04 (0.48,2.26) 1.15(0.47,2.81) 7.54–8.01 1.22 (0.79,1.88) 0.98 (0.59,1.62)
 4th quartile 9.73–11.21 0.97 (0.47, 2.01) 0.66 (0.27,1.58) 8.01–9.93 1.18 (0.74,1.90) 0.77 (0.42,1.41)
P-trend .62 .43 .35 .66
Appendicular lean mass/height2 (kg/m2)
 1st Quartile 5.43–7.03 1 1 3.60–5.27 1 1
 2nd Quartile 7.06–7.74 0.60 (0.33,1.10) 0.49 (0.23,1.05) 5.27–5.78 1.10 (0.67,1.81) 0.91 (0.52,1.59)
 3rd Quartile 7.78–8.51 0.49 (0.25,0.96) 0.46 (0.17,1.27) 5.79–6.40 1.11 (0.68,1.81) 1.03 (0.58,1.82)
 4th Quartile 8.55–10.76 0.45 (0.22,0.89) 0.23(0.10,0.53) 6.40–8.09 1.37 (0.84,2.22) 1.28 (0.72, 2.26)
P-trend .02 <.01 .23 .45
Grip strength (kg)
 1st Quartile 20.00–32.67 1 1 7.67–19.33 1 1
 2nd Quartile 33.00–38.67 1.50 (0.77,2.91) 1.19(0.50, 2.83) 19.33–22.67 1.15 (0.71,1.87) 1.54 (0.89, 2.65)
 3rd Quartile 39.00–44.33 0.84 (0.39,1.79) 0.60 (0.20,1.83) 23.00–27.33 0.88 (0.52,1.47) 0.71 (0.40,1.28)
 4th quartile 44.67–56.33 0.93 (0.45,1.91) 0.94 (0.36, 2.51) 27.33–38.67 1.24 (0.76,2.02) 1.44 (0.83, 2.49)
P-trend .48 .56 .66 .85

CI, confidence interval; HR, hazard ratio.

Model l:age (year) + race (black vs white)

Model 2: age (year) + race (black vs white) + education (≥12 years vs <12 years) +APOE ε4 (carrier vs noncarrier) + diabetes (yes vs no) + hypertension (yes vs no) + physical activity (kcal/week) + triglycerides (mmol/L) + current smoking status (yes vs no) + alcohol consumption (drinks/week) + depression scale (point) + TIA/stroke history (yes vs no) + cancer history (yes vs no) + diagnosis of COPD (yes vs no).