Table 1:
Clinical characteristics of participants in cross-sectional study and baseline characteristics of subjects with anorexia nervosa in longitudinal study. Mean ± SD or median [interquartile range] when data were not normally distributed.
| Cross-sectional study participants (n=89) |
Longitudinal study participants (n=6) |
|
|---|---|---|
| Age (years) | 27.0 [24.5, 31.7] (range: 20-45.7) | 35.7 ± 3.5 (range: 25.3-45.5) |
| BMI (kg/m2) | 22.1 [17.8, 30.8] | 17.1 ± 1.4 |
| Bone mineral density (BMD) | ||
| Lumbar spine BMD (g/cm2) | 0.955 [0.854, 1.078] | 0.808 ± 0.111 |
| Lateral spine BMD (g/cm2) | 0.743 ± 0.149 | 0.628± 0.109 |
| Total Hip BMD (g/cm2) | 0.919 ± 0.170 | 0.739± 0.093 |
| Femoral neck BMD (g/cm2) | 0.799 ± 0.159 | 0.647± 0.087 |
| Total body BMD (g/cm2) | 1.020 ± 0.097 | 0.982 ± 0.052 |
| Bone marrow adipose tissue | ||
| L4 vertebra (lipid/water) | 0.54 [0.40, 0.87] | 1.18 ± 0.42 |
| Femoral epiphysis (lipid/water) | 7.25 ± 2.90 | 8.17 ± 2.17 |
| Femoral diaphysis (lipid/water) | 4.84 [2.61, 7.09] | 7.58 ± 1.71 |
| Femoral metaphysis (lipid/water) | 3.18 [2.04, 4.89] | 5.77 ± 1.96 |
| Microarchitecture parameters at radius | ||
| Trabecular BV/TV (%) | 0.128 [0.109, 0.151] | 0.108 ± 0.024 |
| Trabecular number (1/mm)* | 1.91 [1.71, 2.12] | 1.67 ± 0.24 |
| Trabecular thickness (mm) | 0.066 [0.060, 0.074] | 0.061 [0.057, 0.072] |
| Trabecular separation (mm) | 0.452 [0.407, 0.520] | 0.546 ± 0.093 |
| Cortical thickness (mm) | 0.77 ± 0.18 | 0.61 ± 0.08 |
| Estimates of bone strength at radius | ||
| Stiffness (kN/mm) | 71.1 ± 15.8 | 60.0 ± 2.6 |
| Failure load (kN) | 3.6 ± 0.8 | 2.9 ± 0.2 |
| Microarchitecture parameters at tibia | ||
| Trabecular BV/TV (%) | 0.142 ± 0.038 | 0.115 ± 0.028 |
| Trabecular number (1/mm)* | 1.87 ± 0.42 | 1.70 [1.49, 1.81] |
| Trabecular thickness (mm) | 0.076 ± 0.013 | 0.071 ± 0.008 |
| Trabecular separation (mm) | 0.458 [0.398, 0.540] | 0.510 [0.483, 0.638] |
| Cortical thickness (mm) | 1.17 [0.98, 1.33] | 0.97 ± 0.22 |
| Estimates of bone strength at tibia | ||
| Stiffness (kN/mm) | 200.4 ± 44.9 | 165.6 ± 23.9 |
| Failure load (kN) | 10.1 ± 2.2 | 8.2 ± 1.3 |
| Hematologic parameters | ||
| White blood cell count (x10E3/uL) | 5.6 [4.7, 7.1] | 4.4 ± 1.0 |
| Red blood cell count (x10E6/uL) | 4.30 ± 0.34 | 4.21 ± 0.42 |
| Hemoglobin (g/dL) | 12.9 ± 1.0 | 13.1 ± 1.0 |
| Hematocrit (%) | 38.3 ± 2.7 | 38.9 ± 3.2 |
| Platelet count (x10E3/uL) | 254 ± 60 | 247 ± 63 |