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. 2021 Feb 12;12:128. doi: 10.1186/s13287-021-02186-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Crry expression and Akt activation in iNSC-derived neurons treated with CR2-Crry. a, b RT-QPCR was utilized to determine the expression of the Crry (a) and Akt (b) genes in neurons derived from iNSCs among the PBS (neurons receiving PBS treatment), CHI (neurons receiving CHI mouse serum treatment), and CHI+CR2-Crry (neurons receiving CHI mouse serum and CR2-Crry treatment) groups (n = 3/group; one-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001). c Representative immunoblots depicting the levels of C3d, C9, Crry, active Caspase-3, p-AKT, and AKT in neurons derived from iNSCs among the three groups. d–j Histograms showing the relative levels of C3d (d), C9 (e), Crry (f), active Caspase-3 (g), p-AKT (h), AKT (i), and p-AKT/AKT (j) in neurons derived from iNSCs among the three groups (n = 6/group; one-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001)