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. 2021 Feb 12;16:80. doi: 10.1186/s13023-021-01722-7

Table 2.

Demographic and medical characteristics

Participant demographics Untreated patients (n = 15) Patients treated with asfotase alfa (n = 15)
Mean (SD) Mean (SD)
Age of child (Years) 7.2 (3.3) 8.7 (4.1)
N (%) N (%)
Gender (% Male) 8 (53%) 8 (53%)
Medical history
 Premature loss of deciduous teeth 10 (67%) 15 (100%)
 Bowing of long bones in arms or legs 1 (7%) 8 (53%)
 Recurrent bone fractures 1 (7%) 2 (13%)
 Poorly healing bone fractures 0 1 (7%)
 Short stature 4 (27%) 7 (47%)
 Muscle problems (e.g., muscle weakness, gait problems) 4 (27%) 12 (80%)
 Craniosynostosis 0 5 (33%)
 Chiari malformation 0 3 (20%)
 Seizures 0 2 (13%)
 Chronic headaches 3 (20%) 8 (53%)
 Fatigue 3 (20%) 11 (73%)