. 2021 Feb 12;21:82. doi: 10.1186/s12886-021-01831-8

Table 3.

Vascular density in deep capillary network (DCN) in normal subjects and subtypes of diabetic retinopathy (N = 188)

Groups VD/ Reference group	NL (40 eyes) Median (range) (%)	NDR (39eyes) Median (range) (%)	NPDR (64eyes) Median (range) (%)	PDR (33eyes) Median (range) (%)	P-value Kruskal –Wallis test
Whole image Normal NDR NPDR	60.42 (47.00–64.55)	58.05 (51.34–60.64) < 0.001*	53.84 (41.34–60.67) < 0.001* < 0.001*	51.24 (42.50–57.58) < 0.001* < 0.001* < 0.001*	< 0.001
Fovea Normal NDR NPDR	31.24 (20.30–42.32)	27.72 (20.28–35.46) 0.001*	27.14 (15.48–40.50) < 0.001* 0.225	24.94 (12.19–39.30) < 0.001* 0.050* 0.362*	< 0.001
Para-fovea Normal NDR NPDR	62.89 (50.10–67.22)	60.77 (52.90–63.51) < 0.001*	56.49 (42.94–62.75) < 0.001* < 0.001*	54.16 (42.88–59.89) < 0.001* < 0.001* 0.001*	< 0.001
Superior hemi Normal NDR NPDR	63.45 (50.80–67.76)	61.02 (52.40–64.34) < 0.001*	56.14 (44.02–62.61) < 0.001* < 0.001*	55.33 (41.19–61.91) < 0.001* < 0.001* 0.026*	< 0.001
Inferior hemi Normal NDR NPDR	62.91 (49.50–66.68)	60.51 (52.17–63.94) < 0.001*	55.96 (40.75–63.36) < 0.001* 0.001*	54.07 (43.65–60.35) < 0.001* < 0.001* < 0.001*	< 0.001
Temporal Normal NDR NPDR	61.49 (48.50–64.82)	61.04 (49.90–63.36) 0.011*	53.33 (32.32–61.74) < 0.001* < 0.001*	53.31 (42.70–60.56) < 0.001* < 0.001* 0.004*	< 0.001
Superior Normal NDR NPDR	64.82 (51.20–69.15)	62.09 (53.30–65.34) < 0.001*	58.62 (45.35–63.41) < 0.001* < 0.001*	55.60 (42.14–60.70) < 0.001* < 0.001* 0.005*	< 0.001
Nasal Normal NDR NPDR	62.56 (52.90–67.02)	59.17 (52.40–62.53) < 0.001*	55.64 (35.39–63.44) < 0.001* 0.001*	53.48 (39.92–59.70) < 0.001* < 0.001* 0.020*	< 0.001
Inferior Normal NDR NPDR	63.76 (48.20–67.86)	62.09 (52.23–65.59) < 0.001*	56.76 (43.45–64.21) < 0.001* 0.013*	54.06 (44.73–61.92) < 0.001* < 0.001* < 0.001*	< 0.001

Groups
VD/
Reference group

NL (40 eyes)
Median (range)
(%)

NDR (39eyes)
Median (range)
(%)

NPDR (64eyes)
Median (range)
(%)

PDR (33eyes)
Median (range)
(%)

P-value
Kruskal –Wallis test

Whole image

Normal

NDR

NPDR

60.42

(47.00–64.55)

58.05

(51.34–60.64)

< 0.001*

53.84

(41.34–60.67)

< 0.001*

51.24

(42.50–57.58)

< 0.001*

< 0.001

Fovea

Normal

NDR

NPDR

31.24

(20.30–42.32)

27.72

(20.28–35.46)

0.001*

27.14

(15.48–40.50)

< 0.001*

0.225

24.94

(12.19–39.30)

< 0.001*

0.050*

0.362*

< 0.001

Para-fovea

Normal

NDR

NPDR

62.89

(50.10–67.22)

60.77

(52.90–63.51)

< 0.001*

56.49

(42.94–62.75)

< 0.001*

54.16

(42.88–59.89)

< 0.001*

0.001*

< 0.001

Superior hemi

Normal

NDR

NPDR

63.45

(50.80–67.76)

61.02

(52.40–64.34)

< 0.001*

56.14

(44.02–62.61)

< 0.001*

55.33

(41.19–61.91)

< 0.001*

0.026*

< 0.001

Inferior hemi

Normal

NDR

NPDR

62.91

(49.50–66.68)

60.51

(52.17–63.94)

< 0.001*

55.96

(40.75–63.36)

< 0.001*

0.001*

54.07

(43.65–60.35)

< 0.001*

< 0.001

Temporal

Normal

NDR

NPDR

61.49

(48.50–64.82)

61.04

(49.90–63.36)

0.011*

53.33

(32.32–61.74)

< 0.001*

53.31

(42.70–60.56)

< 0.001*

0.004*

< 0.001

Superior

Normal

NDR

NPDR

64.82

(51.20–69.15)

62.09

(53.30–65.34)

< 0.001*

58.62

(45.35–63.41)

< 0.001*

55.60

(42.14–60.70)

< 0.001*

0.005*

< 0.001

Nasal

Normal

NDR

NPDR

62.56

(52.90–67.02)

59.17

(52.40–62.53)

< 0.001*

55.64

(35.39–63.44)

< 0.001*

0.001*

53.48

(39.92–59.70)

< 0.001*

0.020*

< 0.001

Inferior

Normal

NDR

NPDR

63.76

(48.20–67.86)

62.09

(52.23–65.59)

< 0.001*

56.76

(43.45–64.21)

< 0.001*

0.013*

54.06

(44.73–61.92)

< 0.001*

< 0.001

NDR: No diabetic retinopathy, NL: Normal, NPDR: Nonproliferative diabetic retinopathy, PDR: Proliferative diabetic retinopathy

*Mann- Whitney test