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. 2021 Feb 12;21:22. doi: 10.1186/s40644-021-00391-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Immunohistochemistry: CXCR4 (both photos in same magnification: 200x) coloring in (a) squamous cell carcinoma: (long arrow) is strong positive for CXCR4 (CXCR4 positive inflammatory cells marked with short arrow); and (b) adenocarcinoma (with signet ring cell features; long arrow) scored as negative (less than three CXCR4 positive cells in high power field/HPF; one CXCR4 positive cell marked with short arrow)