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. 2021 Feb 12;19:44. doi: 10.1186/s12951-021-00791-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — In vivo gene silencing effect using fluorescence imaging. 5.0 × 10⁶ cells of pmCherry-N1 transfected HEK293T with 4 µg of free mCherry-siRNA (left) and siRNA/S-R11 nanocomplex (right) were inoculated subcutaneously on both back sides of the BALB/c nude mice. a The mCherry fluorescence intensity was observed on day 0 and day 1 using an in vivo fluorescence imaging system. The left arrow indicated the fluorescence of mCherry-expressing cells with free siRNAs, and the right arrow pointed to that of the S-R11 nanocomplex. b Relative integrated density of each mice was analyzed using the NEOimage software. The relative integrated intensity was calculated by that integrated intensity at day 1 was divided by that at day 0. The data represented mean ± standard deviation (*p < 0.05 and independent n = 4)