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. 2021 Feb 12;23:21. doi: 10.1186/s13058-021-01398-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Concordance between FGFR1 amplification and overexpression and prognostic impact among hormone-positive breast cancer patients. Kaplan-Meier curves representing the impact of FGFR1-amplficiation disease relapse risk in the general HR+ breast cancer cohort (a) or split according to the Lum-A or Lum-B subtypes (b) in the discovery set (H12O series) or in the METABRIC Lum-A/B cohort (c) and (d). e Left panel: concordance between the result of FGFR1 FISH and RNAscope tests. Right panel: examples of concordant results (positive or negative in both tests) or non-concordant results (positive/negative or vice versa) in different cases of the H12O series. f, g Same as a and b according to RNAscope positivity. h Kaplan-Meier curve for distant relapse of patients with FGFR1 amplification and/or FGFR1 mRNA overexpression compared to non-amplified, non-overexpressed cases. Patients at risk are stated under each Kaplan-Meier curve. Vertical ticks represent censoring events