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. 2021 Feb 12;14:48. doi: 10.1186/s12920-021-00894-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — KEGG Pathway Enrichment Analysis of DE mRNAs. The results of Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis acquired by ClueGO/CluePedia software were visualized by a Cytoscape platform, with p < 0.05 as the cutoff value. Terms grouped with a kappa score level (≥ 0.4) are shown as nodes of different colors. The size of each node represents significances whereas only the labels of the most critical terms per group are shown in colors. Edges link small nodes representing genes that are related to the corresponding terms. DE, differentially expressed