Table 1. CpG site differences from EPIC array and the BSAS methods at the 15 loci of differing levels of significance (not significant, nominally significant, and significant after P-value adjustment).
Illumina EPIC array | BSAS | Difference between methods | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cg/Gene | Position in genome | Illumina ID | β difference | P value | FDR Adjusted P value | β difference | P value | FDR Adjusted P value | β difference | |
1 | AHRR | Chr5, GB | cg05575921 | −0.233 | 5.33E−12 | 3.7E−06 | −0.041 | 0.006 | 0.245 | −0.192 |
2 | cg11977356a | Chr19 | cg11977356 | −0.040 | 0.474 | 0.999 | −0.004 | 0.406 | 0.959 | −0.036 |
3 | ITPR1 | Chr3, GB | cg08987995 | −0.001 | 0.572 | 0.999 | 0.005 | 0.820 | 0.822 | −0.006 |
4 | MAGI | Chr7, GB | cg21121803 | −0.008 | 0.572 | 0.999 | −0.007 | 0.809 | 0.959 | −0.0004 |
5 | EHMT2 | Chr6, GB | cg07829740 | 0.005 | 0.037 | 0.999 | −0.015 | 0.071 | 0.579 | 0.020 |
6 | PPM1L | Chr3, GB | cg26406186 | −0.006 | 0.818 | 0.999 | 0.011 | 0.904 | 0.963 | −0.017 |
7 | cg00571101a | Chr12 | cg00571101 | 0.004 | 0.368 | 0.999 | −0.004 | 0.813 | 0.952 | 0.008 |
8 | cg09078959a | Chr5 | cg09078959 | −0.001 | 0.893 | 0.999 | −0.005 | 0.001 | 0.245 | 0.004 |
9 | cg01614625a | Chr7 | cg01614625 | −0.009 | 0.370 | 0.999 | −0.006 | 0.569 | 0.952 | −0.004 |
10 | DP10 | Chr2, GB | cg05868547 | 0.006 | 0.077 | 0.999 | −0.003 | 0.713 | 0.952 | 0.009 |
11 | cg11293828a | Chr12 | cg11293828 | −0.014 | 0.665 | 0.999 | 0.032 | 0.735 | 0.952 | −0.045 |
12 | CHD7 | Chr5, 5′UTR | cg19926587 | −0.007 | 0.960 | 0.999 | −0.006 | 0.429 | 0.959 | −0.001 |
13 | NIPAL4 | Chr5, TSS1500 | cg17695979 | −0.007 | 0.714 | 0.999 | −0.003 | 0.106 | 0.713 | −0.004 |
14 | PRDM5 | Chr4, GB | cg01118724 | −0.004 | 0.734 | 0.999 | 0.005 | 0.116 | 0.713 | −0.009 |
15 | SLC17A7 | Chr19, GB | cg02624701 | −0.043 | 0.312 | 0.999 | 0.018 | 0.646 | 0.952 | −0.061 |
Notes.
When a cg number is listed, then there is no known gene associated with that CpG site. GB-Gene Body.