Table 1.
Polymorphisms of the Serotonin Transporter Gene
| Author/Year/Country | Case/Control Number of Subjects | Age (Years) Case/Control | Diagnosis | AHI (Events/h of Sleep) Case/Control | Genotype Frequency | |||
|---|---|---|---|---|---|---|---|---|
| Genotype | OSAS | Control | ||||||
| 5-HTT VNTR | Yue et al./ 2005/China16 |
104/150 | 42.3±10.1/ NA |
PSG AHI ≥ 10 events/hour of sleep |
NS/ NS |
10/10 10/12 12/12 |
3 20 81 |
1 14 135 |
| Ylmaz et al./ 2005/Turkey37 |
42/162 | NA/ NA |
PSG | NS/ NS |
10/10 10/12 12/12 |
3 13 9 |
14 61 93 |
|
| Yue et al/ 2008/China15 |
254/338 | 45±11.8/ 43.2±12.7 |
PSG AHI ≥ 5 events/hour of sleep |
53.9± 16.4/ NS |
10/10 10/12 12/12 |
6 46 202 |
3 41 294 |
|
| Chen et al./ 2013/China38 |
121/105 | 43.8±3.0/ 43.0±2.7 |
PSG AHI ≥ 5 events/hour of sleep |
42.6±14.8/ 3.7±1.3 |
10/10 10/12 12/12 |
8 24 89 |
1 10 94 |
|
| 5-HTT LPR | Yue et al./ 2005/China16 |
104/150 | 42.3±10.1/ NA |
PSG AHI ≥ 10 events/hour of sleep |
NS/ NS |
S/S S/L L/L |
51 33 20 |
78 54 18 |
| Ylmaz et al./ 2005/Turkey37 |
42/162 | NA/ NA |
PSG | NS/ NS |
S/S S/L L/L |
6 16 4 |
60 71 35 |
|
| Yue et al./ 2008/China15 |
254/338 | 45±11.8/ 43.2±12.7 |
PSG AHI ≥ 5 events/hour of sleep |
53.9± 16.4/ NS |
S/S S/L L/L |
114 106 34 |
35 173 131 |
|
| Chen et al./ 2013/China38 |
121/105 | 43.8±3.0/ 43.0±2.7 |
PSG AHI ≥ 5 events/hour of sleep |
42.6±14.8/ 3.7±1.3 |
S/S S/L L/L |
59 35 27 |
55 34 16 |
|