Table 3.

Peripheral Effects of Serotonin

Peripheral 5-HT	Author, Year	Receptor Implicated	Findings
In the liver	Ramnanan et al, 201020	HTR2B	↑ liver gluconeogenesis ↓ glucose uptake in the fasted state
	Watanabe et al, 201021	HTR 2B	Regulate hepatic bile acid turnover and lipid metabolism
	Crane et al, 201522	HTR2B	↑ steatosis
In the pancreas	Ohta et al, 201123 Almaca et al, 201624 Bennet et al, 201625	HTR3	Acts as a local autocrine/paracrine signal
	Paulmann et al, 200926	HTR3	Is required for normal insulin secretion ↑ insulin exocytosis
	Bennet et al, 201627	HTR 2B	↑ glucose - stimulated insulin secretion
	Almaca et al, 201624	HTR1F	↓ glucagon secretion
	Kim et al, 201046 Ohara-Imaizumi et al, 201328	HTR2B	Increase beta cell mass ↑ glucose-stimulated insulin secretion
In the adipose tissue	Ramnanan et al, 201020	NS	↑ circulating non-esterified fatty acids (NEFA) ↑ glycerol levels
	Crane et al, 201522 Oh et al,20158	HTR3	↓ adipose tissue thermogenesis
	Oh et al,20158	HTR2B HTR2A HTR3	↑ adipose tissue lipolysis during fasting ↑ lipogenesis in adipose tissue in response to high fat diet ↓ adaptive thermogenesis.