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. 2021 Feb 9;13:1189–1204. doi: 10.2147/CMAR.S282684

Figure 1.

Figure 1

GO and KEGG enrichment analyses on 20 predicted targets. (A) The chemical structure of sinomenine. (B) Venn diagram of predicted 58 targets of sinomenine (left) and 1401 targets of breast cancer (right). Twenty-two common targets (middle) between the targets of sinomenine and the targets of breast cancer were identified as candidate target of sinomenine in the treatment of breast cancer. (C) GO enrichment analysis of the 20 predicted targets of sinomenine in the treatment of breast cancer. The green, blue and orange correspond to biological process annotation, cellular component annotation and molecular function annotation. (*1: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; *2: oxidoreductase activity, acting on NAD(P)H). (D) KEGG pathway enrichment analysis of the 20 predicted targets of sinomenine in the treatment of breast cancer. The size of dots indicates the number of genes in the KEGG pathways. (E) Sinomenine-target-pathway network. The red, green and yellow dots correspond to sinomenine, predicted targets and pathways.