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. 2021 Feb 9;13:1189–1204. doi: 10.2147/CMAR.S282684

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© 2021 Li et al.

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PPI network and molecular docking analyses of the targets of sinomenine. (A) PPI network of 18 prediction targets. The size of the circles (nodes) represents the degrees of the gene in the PPI network. The greater size indicates the greater degree. (B–F) Two-dimensional and three-dimensional ligand interaction diagrams of sinomenine and original ligands in MAPK1 (B), NOS1 (C), NOS2 (D), NOS3 (E) and NR3C1 (F). In the two-dimensional ligand interaction diagrams, the red semicircle indicates the hydrophobic interaction of amino acid residues, the amino acid residues involved in hydrogen bonding are shown in green, and the green number indicates the hydrogen bonding distance.