Table I.
Haematological parameters of EAC-bearing mice after treatment with different xanthones, mangosteen and cisplatin at IC50 doses
| Groups (Dose in µM) | WBC (103/µl) | RBC (106/µl) | Hb (g/dl) | Platelets (103/µl) |
|---|---|---|---|---|
| Normal | 14.8±0.7 | 4.88±0.8 | 9.3±0.3 | 309±9 |
| EAC | 92.8±2.6 | 2.88±0.7 | 2.3±0.8 | 856±8 |
| Cisplatin (20) | 35.8±0.8 | 2.7±0.6 | 2.1±0.4 | 200±2 |
| Mangosteen (15) | 20.3±0.3 | 3.15±0.6 | 8.5±0.7 | 326±1 |
| XA-treated (48) | 30.8±0.6 | 4.15±0.4 | 7.5±0.8 | 456±3 |
| XB-treated (48) | 24.6±0.6 | 4.75±0.3 | 7.4±0.5 | 596±4 |
| XC-treated (32.35) | 27.2±0.8 | 5.75±0.2 | 7.9±0.9 | 441±2 |
| XD-treated (8.1) | 17.2±0.2 | 5.05±0.5 | 10±2 | 341±8 |
Values represent mean±SD of six samples in each group. Comparative study of haematological (WBC, RBC, HGB, and PLT) of normal, EAC control, cisplatin-, mangosteen-, XA-, XB-, XC- and XD-treated groups of mice. Significant difference was observed in the haematological parameters of the XD-treated group compared with the EAC control group considering P<0.001. CBC, complete blood count; RBC, red blood cells; WBC, white blood cells; EAC, Ehrlich ascites carcinoma