Table III.
Modulation in antioxidative enzymes in liver cytosol of EAC-bearing mice after XD treatment
| Groups (Dose in µM) | GSH (nmol/mg) | GST (nmol/mg) | GPx (nmol/mg) | SOD (units/mg) | CAT (units/mg) | LPO (mol/mg) |
|---|---|---|---|---|---|---|
| Normal | 2.4±0.5 | 4.65±0.3 | 6.45±0.4 | 12±1.5 | 0.5±0.5 | 1±0.2 |
| Drug control | 2.6±0.3 | 8±0.6 | 8.28±0.6 | 17±6 | 0.4±0.06 | 1.6±0.09 |
| EAC | 0.95±0.08 | 1.75±0.5 | 2.5±0.08 | 5.29±0.8 | 1.4±0.1 | 15±1.2 |
| XD-treated (8.1) | 5.72±1 | 15±5 | 9.9±2 | 35±0.8 | 0.7±0.09 | 1.8±0.09 |
Values represent mean±SD of six samples in each group. Comparative study of modulation of detoxifying enzymes, endogenous LPO in liver cytosol of normal, EAC control and XD-treated groups of mice. Significant difference was observed in the antioxidative enzyme, and endogenous LPO levels of XD-treated group compared with the EAC control group considering P<0.001. GSH, glutathione; GST, glutathione-S-transferase; GPx, glutathione peroxidase; SOD, superoxide dismutase; LPO, lipid peroxidation; CAT, catalase