Table XIV.

Suggested antibiotic-regimens for adults with Mycobacterium malmoense-pulmonary disease

M. malmoense-pulmonary disease	Antibiotic regimens
Non-severe M. malmoense-pulmonary disease (i.e., AFB smear-negative respiratory tract samples, no radiological evidence of lung cavitation or severe infection, mild-moderate symptoms, no signs of systemic illness)	Rifampicin 600 mg daily and ethambutol 15 mg/kg daily and azithromycin 250 mg/daily or clarithromycin 500 mg twice daily. Antibiotic treatment should continue for a minimum of 12 months after culture conversion.
Severe M. malmoense-pulmonary disease (i.e., AFB smear-positive respiratory tract sample, radiological evidence of lung cavitation/severe infection or sever symptoms/signs of systemic illness)	Rifampicin 600 mg daily and ethambutol 15 mg/kg daily and azithromycin 250 mg/daily or clarithromycin 500 mg twice daily and consider intravenous amikacin for up to 3 months or nebulised amikacin. Antibiotic treatment should continue for a minimum of 12 months after culture conversion.

Source: Reproduced with permission from Ref. 1