Table 1:

Structural location of novel acetylated lysine residues and predicted functional role of domains in aromatase protein

Lysine	20% O2		2.5% O2		Structural location	Functional predictions
	Basal	Induced	Basal	Induced
K108	+	+		+	Helix B	Substrate binding
K169	+	+	+	+	Helix D	Structural domain
K242	+	+	+	+	Helix G	Conformation of the active site
K262	+				Helix G	Structural domain
K334	+	+	+	+	Helix J	Substrate binding
K352	+		+		Loop region	Substrate binding
K354	+	+			Helix K	Substrate binding
K376		+		+	Major β-sheet β3	Substrate binding
K390		+			Loop region	Substrate binding
K440				+	Helix L	Heme binding
K448		+			Helix L	Heme binding