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Ki67 immunohistochemistry staining is a marker of proliferative cells. (A and B) Representative Ki67-stained images of mammary tumors treated with 1.25 mg/kg doxorubicin in WT (A) and SDR (B) are shown. Scale bar = 50µm. (C) Blinded cell counting shows a decrease in Ki67-positive cells in mammary tumors found in SDRs (n = 6) relative to WT (n = 3; *P < 0.05; Student’s t-test).
