Table 1:
Demographics and Clinical Measuresa
| SZ (n= 61) | HC (n= 31) | t/X2 | p value | |
|---|---|---|---|---|
| Gender (% male) | 72.1 | 70.96 | 0.014 | .91 |
| Age | 27.84 (8.69) | 28.58 (9.81) | 0.372 | .71 |
| Parental Occupationb | 7.18 (5.67) | 5.84 (4.46) | 14.911 | .31 |
| Smoking status (% smokers) | 62.29 | 29.03 | 9.101 | < .01 |
| Diagnosis | ||||
| Schizophrenia | 50 | |||
| Schizoaffective Disorder | 8 | |||
| Schizophreniform Disorder | 1 | |||
| Psychosis not otherwise specified | 2 | |||
| Prior antipsychotic treatment | ||||
| Antipsychotic naive | 40 | |||
| Antipsychotic free interval (months)c | 22.02 (43.33) | |||
| BPRSd | ||||
| Total | ||||
| Baseline | 49.53 (9.95) | |||
| Week 6e | 31.67 (9.09)f | |||
| Positive | ||||
| Baseline | 14.60 (4.65) | |||
| Week 6g | 6.84 (2.93)h | |||
| Negative | ||||
| Baseline | 7.05 (3.13) | |||
| Week 6g | 5.76 (2.48)h | |||
| RBANSi | ||||
| Total index | 71.14 (14.37) | 90.29 (11.72) | 6.337 | < .01 |
| Immediate memory | 77.52 (16.59) | 95.65 (13.47) | 5.203 | < .01 |
| Visuospatial | 72.38 (15.78) | 82.97 (16.89) | 2.925 | < .01 |
| Language | 83.52 (13.29) | 97.06 (15.79) | 4.254 | < .01 |
| Attention span | 79.32 (19.47) | 96.10 (17.63) | 3.976 | < .01 |
| Delayed memory | 73.32 (19.29) | 92.71 (7.32) | 6.702 | < .01 |
SZ, schizophrenia; HC, healthy control
a
Mean (SD) unless indicated otherwise
b
Ranks determined from Diagnostic Interview for Genetic Studies (1 – 18 scale); higher rank (lower numerical value) corresponds to higher socioeconomic status
c
Antipsychotic free interval is denoted only for those with prior antipsychotic exposure (n= 20)
Brief Psychiatric Rating Scale (1 – 7 scale); positive (conceptual disorganization, hallucinatory behavior, and unusual thought content); negative (emotional withdrawal, motor retardation, and blunted affect)
d
n= 49
e
t= 13.352; p< .01
f
t= 11.030; p< .01
g
t= 3.515; p< .01
h
Repeatable Battery for the Assessment of Neuropsychological Status