Table 2:
Neurometabolites, Spectral Quality, and Tissue Fraction
| Baseline | Week 6 | |||
|---|---|---|---|---|
| HC | SZ | HC | SZ | |
| Neurometabolites | ||||
| ACC | ||||
| NAA | 1.39 (0.11) | 1.36 (0.10) | 1.37 (0.11) | 1.34 (0.09) |
| Glx | 0.71 (0.08) | 0.70 (0.07) | 0.71 (0.07) | 0.70 (0.07) |
| Cho | 0.82 (0.07) | 0.82 (0.11) | 0.80 (0.66) | 0.81 (0.08) |
| Hippocampus | ||||
| NAA | 1.27 (0.10) | 1.29 (0.14) | 1.29 (0.16) | 1.30 (0.16) |
| Glx | 0.60 (0.09) | 0.65 (0.09) | 0.63 (0.12) | 0.65 (0.11) |
| Cho | 0.88 (0.11) | 0.91 (0.12) | 0.86 (0.13) | 0.90 (0.12) |
| Spectral quality indicesa | ||||
| ACC | ||||
| NAA CRLB | 3.50 (0.67) | 3.50 (0.82) | 3.35 (0.35) | 3.44 (0.59) |
| Glx CRLB | 6.62 (1.21) | 6.77 (0.17) | 6.51 (0.93) | 6.76 (0.13) |
| Cho CRLB | 2.59 (0.41) | 2.62 (0.55) | 2.49 (0.26) | 2.59 (0.50) |
| FWHM | 4.80 (0.63) | 4.82 (0.78) | 4.97 (0.75) | 5.01 (0.81) |
| SNR | 11.32 (1.33) | 10.97 (1.50) | 11.59 (1.41) | 11.14 (1.41) |
| Hippocampus | ||||
| NAA CRLB | 3.63 (0.78) | 3.88 (0.95) | 3.62 (0.74) | 4.00 (1.00) |
| Glx CRLB | 9.93 (2.82) | 10.80 (2.98) | 9.73 (2.26) | 10.81 (2.41) |
| Cho CRLB | 2.91 (0.52) | 3.17 (0.76) | 2.91 (0.56) | 3.20 (0.64) |
| FWHM | 8.19 (1.47) | 8.40 (1.76) | 7.98 (1.18) | 8.63 (1.57) |
| SNR | 12.46 (1.38) | 11.93 (1.64) | 12.42 (1.74) | 11.91 (1.51) |
| Voxel tissue fractionb | ||||
| ACC | ||||
| grey matter (%) | 73.99 (3.51) | 73.99 (4.71) | 74.07 (6.28) | 73.86 (5.34) |
| white matter (%) | 13.11 (4.48) | 14.47 (0.54) | 13.67 (6.46) | 14.50 (5.65) |
| Hippocampus | ||||
| grey matter (%) | 62.51 (4.39) | 63.08 (5.56) | 62.38 (5.75) | 61.04 (5.34) |
| white matter (%) | 34.16 (4.83) | 33.74 (5.97) | 34.37 (5.79) | 36.00 (5.04) |
a
None of the spectral indices differed between groups at either timepoint, or across timepoints in either group (all p> .90 after correction for multiple comparisons)
b
Voxel tissue fraction did not differ between groups at either timepoint, or across timepoints in either group (all p> .90 after correction for multiple comparisons)
Abbreviations: HC: Healthy control; SZ: Patient with schizophrenia, schizoaffective disorder, or schizophreniform disorder; ACC: Anterior cingulate cortex; NAA: N-acetyl-aspartate; Glx: Glutamate+glutamine; Cho: Choline; CRLB: Cramer rao lower bounds; FWHM: Full width half maximum; SNR: Signal to noise ratio