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. Author manuscript; available in PMC: 2021 May 15.
Published in final edited form as: Bioorg Med Chem. 2020 Mar 12;28(10):115422. doi: 10.1016/j.bmc.2020.115422

Table 3.

Comparison of the predictive performance of the models before and after rebalancing using under-sampling consensus method, as measured by AUC-ROC values, for the 10 random splitting experiments and splitting on clusters.

Random Splitting Splitting On Clusters
Original Rebalanced Improved Original Rebalanced Improved
0.907 0.916 Y 0.895 0.906 Y
0.888 0.909 Y 0.909 0.922 Y
0.873 0.912 Y 0.877 0.891 Y
0.836 0.882 Y 0.885 0.894 Y
0.916 0.937 Y 0.881 0.894 Y
0.853 0.892 Y 0.873 0.871 N
0.884 0.893 Y 0.890 0.884 N
0.875 0.884 Y 0.891 0.902 Y
0.899 0.910 Y 0.881 0.885 Y
0.878 0.886 Y 0.897 0.892 N
Average 0.881 0.902 Y 0.888 0.894 Y
STD 0.024 0.018 Y 0.010 0.014 N