Skip to main content
. 2020 Jul 6;71(2):385–396. doi: 10.1007/s12020-020-02397-z

Table 2.

Total and sex-stratified prospective associations of thyrotropin and thyroid function with all-cause and cardiovascular mortality

TSH FT4 FT3
HR (95% CI) P value Pinteractiona HR (95% CI) P value Pinteractiona HR (95% CI) P value Pinteractiona
All-cause mortality

 Total population

nevents/ntotal = 380/6054

  Crude 0.93 (0.84–1.03) 0.18 1.29 (1.17–1.42) <0.001 0.88 (0.78–1.00) 0.05
  Age- and sex-adjusted 0.99 (0.90–1.10) 0.89 0.90 1.24 (1.13–1.37) <0.001 0.03 0.99 (0.89–1.09) 0.81 0.002
  Multivariable modelb 1.02 (0.92–1.14) 0.65 0.87 1.18 (1.07–1.30) 0.001 0.01 0.99 (0.89–1.10) 0.81 0.006

 Men

nevents/ntotal = 288/3149

  Crude 0.97 (0.85–1.09) 0.58 1.10 (0.99–1.24) 0.09 0.60 (0.51–0.70) <0.001
  Age-adjusted 1.00 (0.89–1.13) 0.99 1.17 (1.04–1.31) 0.007 0.91 (0.78–1.07) 0.25
  Multivariable modelc 1.00 (0.89–1.14) 0.95 1.14 (1.01–1.27) 0.03 0.92 (0.79–1.07) 0.27

 Women

nevents/ntotal = 92/2905

  Crude 1.00 (0.82–1.22) 0.99 1.68 (1.37–2.05) <0.001 1.11 (0.99–1.24) 0.08
  Age-adjusted 0.99 (0.82–1.19) 0.89 1.56 (1.28–1.90) <0.001 1.18 (1.05–1.32) 0.005
  Multivariable modelc 1.07 (0.89–1.30) 0.47 1.47 (1.19–1.82) <0.001 1.18 (1.02–1.35) 0.02
Cardiovascular mortality

 Total population

nevents/ntotal = 103/6054

  Crude 0.89 (0.73–1.09) 0.26 1.40 (1.16–1.69) <0.001 0.73 (0.57–0.93) 0.01
  Age- and sex-adjusted 0.97 (0.79–1.18) 0.75 0.87 1.34 (1.11–1.61) 0.002 0.40 0.86 (0.66–1.12) 0.27 0.46
  Multivariable modelb 0.98 (0.80–1.20) 0.86 0.84 1.23 (1.02–1.49) 0.03 0.22 0.91 (0.70–1.18) 0.48 0.67

 Men

nevents/ntotal = 83/3149

  Crude 0.92 (0.72–1.16) 0.48 1.21 (0.98–1.49) 0.07 0.50 (0.37–0.67) <0.001
  Age-adjusted 0.96 (0.77–1.21) 0.73 1.29 (1.04–1.59) 0.02 0.83 (0.61–1.13) 0.27
  Multivariable modelc 0.93 (0.73–1.18) 0.56 1.23 (1.00–1.52) 0.05 0.87 (0.64–1.18) 0.38

 Women

nevents/ntotal = 20/2905

  Crude 1.02 (0.67–1.55) 0.93 1.82 (1.19–2.78) 0.005 0.92 (0.53–1.61) 0.78
  Age-adjusted 1.00 (0.67–1.50) 0.99 1.61 (1.07–2.42) 0.02 1.02 (0.59–1.76) 0.95
  Multivariable modelc 1.17 (0.77–1.78) 0.47 1.46 (0.92–2.31) 0.10 0.96 (0.54–1.70) 0.89

Point estimates are expressed per SD increment in the predictor

CI confidence interval, FT3 free triiodothyronine, FT4 free thyroxine, HR hazard ratio, TSH thyrotropin

aEvidence against the null hypothesis of no effect modification by sex on the association of the thyroid function parameter and the specific outcome concerned

bAdjusted for age, sex, current smoking, body-mass index, systolic blood pressure, use of antihypertensive drugs, total cholesterol/high-density lipoprotein ratio, ln triglycerides, use of lipid-lowering drugs, type 2 diabetes, high-sensitive C-reactive protein, history of cardiovascular disease, estimated glomerular filtration rate, and ln urinary albumin excretion

cAdjusted for all potential confounders except for sex