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Adjusted changes in alanine amino transferase (ALT; a & b), aspartate aminotransferase (AST; c & d) and gamma-glutamyl transferase (GGT; e & f) in men and women during CALERIE phase 2. Dashed lines represent calorie restriction (CR), whereas solid lines represent ad libitum (AL) control group. *P < 0.05 between CR and AL groups
