Table 2.

Baseline concentrations of liver-related biomarkers in CALERIE phase 2 participants.

	Men		Women		Overall
	AL (n = 22)	CR (n = 44)	AL (n = 53)	CR (n = 99)	AL (n = 75)	CR (n = 143)
ALT (IU/L)	26 (12)	24 (9)	15 (5)	16 (6)	18 (9)	18 (8)
AST (IU/L)	22 (6)	22 (5)	19 (4)	19 (6)	20 (5)	20 (5)
ALP (IU/L)	70 (16)	65 (16)	58 (15)	57 (18)	62 (16)	59 (18)
GGT (IU/L)	27 (19)	24 (13)	14 (6)	16 (11)	18 (13)	18 (12)
Bilirubin (mg/dL)	0.71 (0.46)	0.62 (0.30)	0.59 (0.42)	0.48 (0.23)	0.63 (0.43)	0.52 (0.26)

Abbreviations: AL, ad libitum; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CR, calorie restriction; GGT, gamma-glutamyl transferase.

Values are mean (± SD).

Wilcoxon rank sum test revealed significant differences between men and women for all biomarkers (P < 0.01), but no significant differences between CR and AL groups were observed (P ≥ 0.15).