Table 4.

Moderated Effect of Age on the Associations between Insomnia and Depression Symptoms and Inflammatory Markers

	CRP (ng/mL)			IL-6 (pg/mL)			IL-1β (pg/mL)			TNF-α (pg/mL)
Predictors	Estimates	CI	p	Estimates	CI	p	Estimates	CI	p	Estimates	CI	p
(Intercept)	1.90	−2.12 – 5.92	0.352	0.05	−0.52 – 0.61	0.873	−1.92	−3.01 – −0.83	0.001	0.06	−0.37 – 0.48	0.797
Depression	−0.29	−0.55 – −0.02	0.034	−0.03	−0.07 – 0.01	0.106	−0.01	−0.08 – 0.06	0.846	−0.03	−0.06 – −0.00	0.033
Age	−0.07	−0.16 – 0.03	0.186	−0.01	−0.02 – 0.01	0.221	0.00	−0.02 – 0.03	0.802	−0.01	−0.02 – 0.00	0.171
Insomnia	−0.06	−0.21 – 0.09	0.423	−0.02	−0.04 – 0.00	0.068	−0.00	−0.04 – 0.04	0.915	−0.01	−0.03 – 0.00	0.163
Gender	−0.73	−1.47 – 0.02	0.056	−0.03	−0.13 – 0.08	0.595	0.06	−0.14 – 0.27	0.525	0.09	0.01 – 0.16	0.033
Ethnicity	−0.32	−0.99 – 0.34	0.338	0.04	−0.05 – 0.13	0.413	−0.04	−0.22 – 0.14	0.690	−0.06	−0.14 – 0.01	0.080
Race	0.49	−0.01 – 0.99	0.056	0.00	−0.07 – 0.07	0.947	0.06	−0.08 – 0.19	0.424	0.03	−0.02 – 0.09	0.236
BMI	0.19	0.15 – 0.23	<0.001	0.02	0.02 – 0.03	<0.001	0.01	−0.00 – 0.02	0.136	0.01	0.01 – 0.01	<0.001
Depression x Age	0.01	0.00 – 0.02	0.017	0.00	−0.00 – 0.00	0.160	0.00	−0.00 – 0.00	0.806	0.00	0.00 – 0.00	0.038
Insomnia x Age	0.00	−0.00 – 0.01	0.386	0.00	−0.00 – 0.00	0.162	0.00	−0.00 – 0.00	0.775	0.00	−0.00 – 0.00	0.160
Observations	380			379			378			377
R2 / R2 adjusted	0.279 / 0.262			0.219 / 0.199			0.037 / 0.013			0.107 / 0.085

Note. IL-6 = interluekin-6. CRP = C-reactive protein. TNF-α = tumor-necrosis factor alpha. IL-1β = interleukin-1 beta. BMI = body mass index. Bold values indicate p < .05 associations. CRP was square-root transformed, and IL-6, IL-1β, and TNF-α were all log 10 transformed. Estimates represent unstandardized betas. CI = 95% confidence intervals. Race is coded as 0 = any other race, 1 = white. Ethnicity is coded as 1 = non-Hispanic/Latinx, 2 = Hispanic/Latinx.