Table 2.
Relative mRNA level by brain region in alcohol use disorder (AUD) subjects versus controls
| mRNA | Region | mRNA levels (mean ± SER) | p‐value | |
|---|---|---|---|---|
| Control | AUD | |||
| HDAC2 | PFC | 1.054 ± 0.098, n = 13 | 1.353 ± 0.236, n = 11 | t = 1.233, df = 22, p = .230 |
| HDAC6 | PFC | 1.016 ± 0.050, n = 13 | 1.045 ± 0.074, n = 11 | t = 0.328, df = 22, p = .745 |
| TSPO | PFC | 1.049 ± 0.09, n = 13 | 1.368 ± 0.125, n = 10 | t = 2.137, df = 21, p = .043 |
| HDAC2 | HPP | 1.078 ± 0.114, n = 13 | 0.920 ± 0.098, n = 11 | t = 1.018, df = 22, p = .319 |
| HDAC6 | HPP | 1.139 ± 0.162, n = 13 | 0.984 ± 0.106, n = 11 | t = 0.767, df = 22, p = .4511 |
| TSPO | HPP | 1.094 ± 0.128, n = 13 | 0.972 ± 0.053, n = 11 | t = 0.819, df = 22, p = .421 |
| HDAC2 | NAc | 1.023, n = 11 | 1.033, n = 8 | U = 36, p = .544 |
| HDAC6 | NAc | 1.037, n = 12 | 1.00, n = 9 | U = 41, p = .382 |
| TSPO | NAc | 1.058, n = 12 | 1.139, n = 9 | U = 46, p = .601 |
| HDAC2 | AMY | 1.079 ± 0.117, n = 13 | 1.967 ± 0.169, n = 11 | t = 4.419, df = 22, p = .0002 |
| HDAC6 | AMY | 1.040 ± 0.082, n = 13 | 1.667 ± 0.214, n = 11 | t = 2.954, df = 22, p = .0073 |
| TSPO | AMY | 1.053 ± 0.095, n = 13 | 1.756 ± 0.184, n = 11 | t = 3.541, df = 22, p = .0018 |
Results are expressed as mean ± SEM.
Abbreviations: AMY, amygdala; HPP, hippocampus; NAc, nucleus accumbens; PFC, prefrontal cortex.