Table 2. Vitamin D receptor polymorphisms association with biochemical, inflammatory and oxidative stress parameters in the children included in the study.
| SNP ID | Parameter | Genotype | Mean (SEM) | Difference (95% CI)† | P | Best model |
|---|---|---|---|---|---|---|
| rs2228570 Fokl A>G | Glucose (mmol/L) | G/G-A/G | 4.99 (0.05) | −0.16 (−0.47 to 0.13) | 0.28 | R |
| A/A | 4.83 (0.14) | |||||
| Total-C (mmol/L) | G/G-A/G | 4.11 (0.07) | 0.20 (−0.21 to 0.61) | 0.35 | R | |
| A/A | 4.30 (0.16) | |||||
| HDL-C (mmol/L) | G/G-A/G | 1.36 (0.03) | 0.17 (0.01 to 0.32) | 0.04 | R | |
| A/A | 1.52 (0.09) | |||||
| Vitamin D (nmol/L) | G/G | 74.6 (3.0) | −3.5 (−9.2 to 2.3) | 0.25 | A | |
| A/G | 70.6 (2.7) | |||||
| A/A | 68.4 (6.0) | |||||
| IL-6 (pg/mL) | G/G-A/A | 3.69 (0.79) | −0.61 (−1.26 to 2.47) | 0.52 | OD | |
| A/G | 4.30 (0.50) | |||||
| TNF-α (pg/mL) | G/G-A/G | 8.72 (0.64) | −0.34 (−4.05 to 3.56) | 0.86 | R | |
| A/A | 8.38 (1.98) | |||||
| IFN-γ (pg/mL) | G/G | 1.35 (0.27) | −0.13 (−0.50 to 0.25) | 0.51 | A | |
| A/G | 1.27 (0.13) | |||||
| A/A | 1.05 (0.17) | |||||
| 8-iso-PGF2α (pg/mL) | G/G-A/G | 62.2 (6.9) | 14.7 (−28.3 to 57.6) | 0.50 | R | |
| A/A | 76.9 (26.9) | |||||
| Nitrates (µM) | G/G | 40.6 (6.4) | −5.9 (−14.1 to 2.4) | 0.16 | A | |
| A/G | 33.2 (2.0) | |||||
| A/A | 30.3 (2.1) | |||||
| rs7975232 ApaI C>A | Glucose (mmol/L) | C/C | 5.02 (0.72) | −0.07 (−0.19 to 0.07) | 0.33 | A |
| A/C | 4.97 (0.08) | |||||
| A/A | 4.89 (0.09) | |||||
| Total-C (mmol/L) | C/C | 4.08 (0.09) | 0.08 (−0.20 to 0.35) | 0.60 | D | |
| A/C-A/A | 4.16 (0.09) | |||||
| HDL-C (mmol/L) | C/C-A/C | 1.35 (0.03) | 0.11 (−0.03 to 0.21) | 0.12 | R | |
| A/A | 1.45 (0.04) | |||||
| Vitamin D (nmol/L) | C/C | 72.6 (3.2) | −0.8 (−9.0 to −8.0) | 0.90 | D | |
| A/C-A/A | 71.9 (2.5) | |||||
| IL-6 (pg/mL) | C/C-A/C | 3.97 (0.43) | −1.46 (−3.13 to 0.22) | 0.09 | R | |
| A/A | 2.51 (0.50) | |||||
| TNF-α (pg/mL) | C/C | 10.17 (1.16) | −1.97 (−3.62 to 0.33) | 0.02 | A | |
| A/C | 8.89 (0.88) | |||||
| A/A | 6.12 (1.13) | |||||
| IFN-γ (pg/mL) | C/C-A/C | 1.37 (0.16) | −0.41 (−1.02 to 0.18) | 0.17 | R | |
| A/A | 0.95 (0.14) | |||||
| 8-iso-PGF2α (pg/mL) | C/C | 85.8 (17.3) | −22.4 (−41.1 to −3.7) | 0.02 | A | |
| A/C | 60.9 (8.9) | |||||
| A/A | 41.4 (7.1) | |||||
| Nitrates (µM) | C/C-A/C | 38.1 (3.5) | −10.4 (−23.5 to 2.6) | 0.12 | R | |
| A/A | 27.6 (1.3) | |||||
| A/A | 88.1 (1.7 |
8-iso-PGF2α, 8-isoprostaglandin F2α; A, additive; CI, confidence interval; D, dominant; HDL-C, high-density lipoprotein cholesterol; IFN-γ, interferon gamma; IL-6, interleukin-6; OD, overdominant; R, recessive; SEM, standard error of the mean; TNF-α, tumor necrosis factor-α; Total-C, total cholesterol. †Maximum significative difference between means.