Table 1. Association between WTAP gene polymorphisms and neuroblastoma risk.
| Genotype | Cases (N=896) | Controls (N=1,732) | Pa | Crude OR (95% CI) | P | Adjusted OR (95% CI)b | Pb |
|---|---|---|---|---|---|---|---|
| rs9457712 G>A (HWE =0.213) | |||||||
| GG | 601 (67.08) | 1,167 (67.38) | 1.00 | 1.00 | |||
| GA | 259 (28.91) | 500 (28.87) | 1.01 (0.84–1.20) | 0.949 | 1.00 (0.84–1.20) | 0.963 | |
| AA | 36 (4.02) | 65 (3.75) | 1.08 (0.71–1.64) | 0.731 | 1.10 (0.72–1.67) | 0.670 | |
| Additive | 0.804 | 1.02 (0.88–1.18) | 0.804 | 1.02 (0.88–1.18) | 0.775 | ||
| Dominant | 295 (32.92) | 565 (32.62) | 0.875 | 1.01 (0.85–1.20) | 0.875 | 1.02 (0.85–1.21) | 0.869 |
| Recessive | 860 (95.98) | 1,667 (96.25) | 0.738 | 1.07 (0.71–1.63) | 0.735 | 1.09 (0.72–1.66) | 0.671 |
| rs1853259 A>G (HWE =0.185) | |||||||
| AA | 333 (37.17) | 624 (36.03) | 1.00 | 1.00 | |||
| AG | 431 (48.10) | 853 (49.25) | 0.95 (0.79–1.13) | 0.543 | 0.94 (0.79–1.12) | 0.476 | |
| GG | 132 (14.73) | 255 (14.72) | 0.97 (0.76–1.24) | 0.809 | 0.96 (0.75–1.23) | 0.736 | |
| Additive | 0.688 | 0.98 (0.87–1.10) | 0.688 | 0.97 (0.86–1.09) | 0.605 | ||
| Dominant | 563 (62.83) | 1,108 (63.97) | 0.566 | 0.95 (0.81–1.13) | 0.565 | 0.94 (0.80–1.11) | 0.488 |
| Recessive | 764 (85.27) | 1,477 (85.28) | 0.995 | 1.00 (0.80–1.26) | 0.995 | 0.99 (0.79–1.25) | 0.958 |
| rs7766006 G>T (HWE =0.799) | |||||||
| GG | 304 (33.93) | 584 (33.72) | 1.00 | 1.00 | |||
| GT | 430 (47.99) | 839 (48.44) | 0.99 (0.82–1.18) | 0.866 | 0.99 (0.82–1.18) | 0.870 | |
| TT | 162 (18.08) | 309 (17.84) | 1.01 (0.80–1.27) | 0.953 | 1.02 (0.80–1.29) | 0.898 | |
| Additive | 0.992 | 1.00 (0.89–1.12) | 0.992 | 1.00 (0.90–1.13) | 0.943 | ||
| Dominant | 592 (66.07) | 1,148 (66.28) | 0.914 | 0.99 (0.84–1.18) | 0.914 | 0.99 (0.84–1.18) | 0.938 |
| Recessive | 734 (81.92) | 1,423 (82.16) | 0.879 | 1.02 (0.82–1.25) | 0.879 | 1.03 (0.83–1.26) | 0.821 |
| Combined effect of risk genotypesc | |||||||
| 0 | 429 (47.88) | 850 (49.08) | 1.00 | 1.00 | |||
| 1 | 144 (16.07) | 266 (15.36) | 1.07 (0.85–1.36) | 0.555 | 1.07 (0.85–1.35) | 0.577 | |
| 2 | 323 (36.05) | 616 (35.57) | 1.04 (0.87–1.24) | 0.674 | 1.05 (0.88–1.25) | 0.601 | |
| 1–2 | 467 (52.12) | 882 (50.92) | 0.561 | 1.05 (0.89–1.23) | 0.561 | 1.06 (0.90–1.24) | 0.518 |
a, χ2 test for genotype distributions between neuroblastoma patients and cancer-free controls; b, adjusted for age and gender; c, risk genotypes were rs9457712 GA/AA, rs1853259 AA and rs7766006 TT. OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium.