Table 5. Univariate and multivariate analyses of clinical parameters which influence on the diagnosis of malignancy/NIFTP.
| Variable | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | ||
| Gender | |||||
| Female | ref. | ref. | |||
| Male | 1.642 (1.039–2.596) | 0.034 | 2.027 (1.042–3.944) | 0.037 | |
| Age (years) | |||||
| ≥55 | ref. | ||||
| <55 | 1.693 (1.116–2.569) | 0.013 | |||
| Follicular neoplasm subtype | |||||
| Hürthle | ref. | ref. | |||
| Architectural atypia | 2.274 (1.286–3.678) | <0.004 | 1.515 (0.693–3.312) | 0.298 | |
| PTC-related nuclear changes | 18.360 (5.876–57.371) | <0.001 | 10.762 (3.002–38.575) | <0.001 | |
| BRAFV600E mutation* | |||||
| Negative | ref. | ||||
| Positive | 5.933 (1.291–27.274) | 0.022 | |||
| NRAS mutation** | |||||
| Negative | ref. | ref. | |||
| Positive | 2.703 (1.372–5.324) | 0.004 | 2.483 (1.212–5.086) | 0.013 | |
Data are expressed as odds ratio (OR) and 95% confidence interval (CI). A P value <0.05 was considered statistically significant. *, BRAFV600E mutation test was performed in 193 patients; **, NRAS mutation test was performed in 220 patients. NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; PTC, papillary thyroid carcinoma.