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. 2021 Jan;10(1):130–142. doi: 10.21037/gs-20-569

Table 3. DFS and OS by clinicopathological parameters and expressions of all-PRLR and LF-PRLR.

Characteristics Cases, n DFS OS
Events, n 5-year survival, % P value Events, n 5-year survival, % P value
Age at diagnosis, years 0.925 0.612
   ≤50 109 20 81.5 9 92.8
   >50 226 43 82.5 23 90.4
Tumor size, mm 0.002 0.004
   ≤20 121 12 90.4 4 96.6
   >20 214 51 77.5 28 88.1
Histological grading 0.456 0.291
   I/II 196 35 84.2 16 93.5
   III 139 28 79.2 16 87.9
Lymphovascular invasion 0.001 0.013
   Absence 229 32 86.8 16 93.4
   Presence 106 31 72.0 16 86.4
Axillary nodal metastasis <0.001 0.001
   Absence 157 14 92.0 6 95.8
   Presence 178 49 735 26 87.1
Staging <0.001 <0.001
   I/II 243 28 88.8 11 95.5
   III 92 35 64.6 21 79.8
ER 0.820 0.014
   Negative 102 19 81.2 16 83.8
   Positive 233 44 82.5 16 94.5
PR 0.302 0.005
   Negative 124 26 80.5 19 84.1
   Positive 211 37 83.2 13 95.4
HER2 0.317 0.028
   Negative 239 43 83.8 18 93.8
   Positive 96 20 78.0 14 84.7
All-PRLR 0.179 0.480
   Negative/low expression 101 14 86.1 8 92.9
   High expression 234 49 80.4 24 90.4
LF-PRLR 0.717 0.954
   Negative expression 152 28 83.0 15 92.0
   Low/high expression 183 35 81.5 17 90.4

DFS, disease-free survival; OS, overall survival; all-PRLR, all prolactin receptor isoforms; LF-PRLR, long-form prolactin receptor; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2.