Table 3. DFS and OS by clinicopathological parameters and expressions of all-PRLR and LF-PRLR.
Characteristics | Cases, n | DFS | OS | |||||
---|---|---|---|---|---|---|---|---|
Events, n | 5-year survival, % | P value | Events, n | 5-year survival, % | P value | |||
Age at diagnosis, years | 0.925 | 0.612 | ||||||
≤50 | 109 | 20 | 81.5 | 9 | 92.8 | |||
>50 | 226 | 43 | 82.5 | 23 | 90.4 | |||
Tumor size, mm | 0.002 | 0.004 | ||||||
≤20 | 121 | 12 | 90.4 | 4 | 96.6 | |||
>20 | 214 | 51 | 77.5 | 28 | 88.1 | |||
Histological grading | 0.456 | 0.291 | ||||||
I/II | 196 | 35 | 84.2 | 16 | 93.5 | |||
III | 139 | 28 | 79.2 | 16 | 87.9 | |||
Lymphovascular invasion | 0.001 | 0.013 | ||||||
Absence | 229 | 32 | 86.8 | 16 | 93.4 | |||
Presence | 106 | 31 | 72.0 | 16 | 86.4 | |||
Axillary nodal metastasis | <0.001 | 0.001 | ||||||
Absence | 157 | 14 | 92.0 | 6 | 95.8 | |||
Presence | 178 | 49 | 735 | 26 | 87.1 | |||
Staging | <0.001 | <0.001 | ||||||
I/II | 243 | 28 | 88.8 | 11 | 95.5 | |||
III | 92 | 35 | 64.6 | 21 | 79.8 | |||
ER | 0.820 | 0.014 | ||||||
Negative | 102 | 19 | 81.2 | 16 | 83.8 | |||
Positive | 233 | 44 | 82.5 | 16 | 94.5 | |||
PR | 0.302 | 0.005 | ||||||
Negative | 124 | 26 | 80.5 | 19 | 84.1 | |||
Positive | 211 | 37 | 83.2 | 13 | 95.4 | |||
HER2 | 0.317 | 0.028 | ||||||
Negative | 239 | 43 | 83.8 | 18 | 93.8 | |||
Positive | 96 | 20 | 78.0 | 14 | 84.7 | |||
All-PRLR | 0.179 | 0.480 | ||||||
Negative/low expression | 101 | 14 | 86.1 | 8 | 92.9 | |||
High expression | 234 | 49 | 80.4 | 24 | 90.4 | |||
LF-PRLR | 0.717 | 0.954 | ||||||
Negative expression | 152 | 28 | 83.0 | 15 | 92.0 | |||
Low/high expression | 183 | 35 | 81.5 | 17 | 90.4 |
DFS, disease-free survival; OS, overall survival; all-PRLR, all prolactin receptor isoforms; LF-PRLR, long-form prolactin receptor; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2.