Table 1. Studies investigating the potential association between breast implants and malignancy.
| Authors | Year of publication | Country | Article classification | Sample size | Follow-up | Conclusion on silicone implants |
|---|---|---|---|---|---|---|
| Cancer | ||||||
| Brinton et al. | 2000 | USA | Retrospective cohort | 13,488 | Not stated | Do not alter risk of breast cancer |
| Mellemkjaer et al. | 2000 | Denmark | Retrospective cohort | 1,653 | Not stated | Cancer risk not increased |
| Brinton et al. | 2001 | USA | Retrospective cohort | 13,488 | Avg. 12 years | Excess of cervical, vulvar, lung, and brain cancer but likely secondary to lifestyle choices |
| Pukkala et al. | 2002 | Finland | Retrospective cohort | 2,171 | 29 years max | Are not a cause of cancer and do not delay breast cancer detection |
| Breiting et al. | 2004 | Denmark | Retrospective cohort | 190 | Avg. 19 years | Associated with local complications but no systemic illness |
| Friis et al. | 2006 | Denmark | Retrospective cohort | 2,763 | 30 years max | Are not carcinogenic |
| McLaughlin et al. | 2006 | Sweden | Retrospective cohort | 3,486 | Avg 18.4 years | No increased risk of any cancer type |
| Brisson et al. | 2006 | Canada | Retrospective cohort | 24,558 | Not stated | No increased long-term risk of developing cancer |
| Balk and Raman | 2016 | USA | Systematic review | 32 studies | Not stated | Inconclusive evidence about association with long-term health outcomes |
| Corneos et al. | 2018 | USA | Retrospective cohort | 99,993 | 2–7 years | Associated with increased risk of certain rare harms |
Outlines key articles since 2000 that review the risk of cancer in patients with breast implants.