Table 3.
Descriptive statistics of proteins in the immune response panel by groups.
| Protein Names | Groups |
Effect Size | p-value | |||
|---|---|---|---|---|---|---|
| Control | Mild | Severe | Critical | |||
| Median (Min-Max) | Median (Min-Max) | Median (Min-Max) | Median (Min-Max) | |||
| PPP1R9B | 6.7a(5.3-7.29) | 1.22b(0.74-3.72) | 1.83b(0.63-2.45) | 1.77b(0.73-3.62) | 0.63 (Large) | <0.0001* |
| GLB1 | 3.8a(1.61-4.64) | 0.8b(0.28-1.49) | 0.77b(0.36-1.68) | 1.61c(0.45-2.53) | 0.71 (Large) | <0.0001* |
| PSIP1 | 4.48a(2.72-6.71) | 2.16b(1.54-4.56) | 3.87a(3.16-5.43) | 4.43a(3.47-7.4) | 0.49 (Large) | <0.0001* |
| ZBTB16 | 4.09a(2.53-8.12) | 0.4b(-0.07-2.25) | 1.2b,c(0.42-2.69) | 1.45c(0.54-3.28) | 0.71 (Large) | <0.0001* |
| IRAK4 | 6.74a(5-7.89) | 1.56b(0.85-3.69) | 2.35b(1.29-3.51) | 2.04b(1.12-4.29) | 0.64 (Large) | <0.0001* |
| HCLS1 | 8.19a(6.97-8.74) | 3.67b(2.46-6) | 5.37c(4.15-6.71) | 5.33c(4.08-7.51) | 0.69 (Large) | <0.0001* |
| CNTNAP2 | 1.97a(1.39-3.32) | 1.46b(0.65-1.99) | 1.39b(0.69-1.76) | 1.09b(0.56-2.3) | 0.37 (Large) | <0.0001* |
| CLEC4G | 3.34a(2.58-4.47) | 3.4a(2.85-4.53) | 3.88a,b(3.08-4.86) | 4.32b(3.37-6.35) | 0.36 (Large) | <0.0001* |
| IRF9 | 3.11a(2.09-4.31) | 1.33b(0.85-1.87) | 1.74b,c(1.15-2.85) | 2.21c(1.23-5.42) | 0.58 (Large) | <0.0001* |
| EDAR | 4.22a(2.3-5.71) | 1.72b(1.11-3.92) | 1.36b(0.9-1.7) | 1.47b(0.92-2.68) | 0.63 (Large) | <0.0001* |
| IL6 | 2.21a(1.47-3.79) | 1.9a(1.16-4.87) | 5.02b(4.25-8.14) | 7.13c(2.91-10.47) | 0.64 (Large) | <0.0001* |
| DGKZ | 1.44a(0.58-2.65) | 0.39b(-0.1-0.68) | 0.6b(0.29-0.89) | 0.57b(0.02-3.48) | 0.54 (Large) | <0.0001* |
| CLEC4C | 3.88a,b(2.58-4.88) | 3.98a(3.3-5.44) | 3.51b,c(2.41-4.31) | 3.05c(2.07-4.27) | 0.25 (Large) | <0.0001* |
| IRAK1 | 4.82a(3.32-6.07) | 1.6b(1.13-2.97) | 2.19b,c(1.68-2.81) | 2.39c(1.9-4.37) | 0.72 (Large) | <0.0001* |
| CLEC4A | 4.19a(3.05-4.52) | 3.84b(2.85-4.24) | 2.98c(2.14-3.61) | 2.94c(2.31-4) | 0.60 (Large) | <0.0001* |
| PRDX1 | 5.32a(3.86-6.62) | 1.24b(0.71-6.25) | 2.14b,c(1.28-4.48) | 2.81c(1.83-5.08) | 0.67 (Large) | <0.0001* |
| PRDX3 | 2.4a(-0.07-4.38) | 0.63b(-0.98-0.43) | 0.26b,c(-0.65-0.91) | 0.25c(-0.32-1.47) | 0.70 (Large) | <0.0001* |
| FGF2 | 3.64a(2.03-5.74) | 0.24b(-0.13-1.31) | 0.98b(0.15-1.83) | 0.44b(-0.07-1.94) | 0.64 (Large) | <0.0001* |
| PRDX5 | 7.65a(7.06-8.44) | 3.27b(2.53-6.61) | 4.55c(3.79-6.31) | 5.19c(4.04-7.05) | 0.70 (Large) | <0.0001* |
| TRIM5 | 3.83a(2.42-5.49) | 1.2b(0.92-2.47) | 1.66b,c(1.43-3.49) | 2.29c(1.57-4.61) | 0.67 (Large) | <0.0001* |
| DCTN1 | 7.42a(5.65-8.63) | 2.81b(1.54-4.47) | 3.37b,c(2.46-3.9) | 3.6c(2.6-7.18) | 0.63 (Large) | <0.0001* |
| ITGA6 | 5.1a(1.43-6.34) | 0.88b(0.03-3.98) | 0.56b(0.12-1.17) | 0.69b(-0.11-2.09) | 0.59 (Large) | <0.0001* |
| CDSN | 3.16a(2.28-3.96) | 2.6a(1.47-6.23) | 2.29a(1.89-3.65) | 2.59a(1.54-4.55) | 0.13 (Large) | 0.002* |
| FXYD5 | 2.25a(0.77-4.13) | 0.02b(-0.51-0.85) | 0.32b,c(0.03-1.25) | 0.56c(-0.7-3.06) | 0.64 (Large) | <0.0001* |
| TRAF2 | 3.19a(2.16-5.3) | 1.31b(0.86-4.42) | 1.81b(1.08-2.55) | 1.73b(1.09-3.7) | 0.54 (Large) | <0.0001* |
| LILRB4 | 3.05a(2.09-4.62) | 3.42a(2.65-5.38) | 4.86b(4.19-6.22) | 5.47c(4.62-7.38) | 0.64 (Large) | <0.0001* |
| NTF4 | 1.89a(1.31-2.81) | 1.91a(1.4-3.54) | 1.54a(1.33-1.95) | 1.58a(0.95-2.53) | 0.09 (Large) | 0.011* |
| KRT19 | 2.17a(1.17-4.07) | 1.84a(0.08-4.19) | 4.84b(2.69-7.31) | 5.57b(3.11-7.72) | 0.63 (Large) | <0.0001* |
| HNMT | 9.12a(7.7-10.2) | 8.96a(6.91-10.66) | 9.55a,b(8.9-11.63) | 9.91b(9.13-14.96) | 0.31 (Large) | <0.0001* |
| CCL11 | 7.23a(6.32-8.56) | 7.41a(5.32-8.33) | 6.69a(6.21-7.59) | 7.11a(6.23-8.04) | 0.06 (Large) | 0.036* |
| EGLN1 | 1.77a(1.03-2.59) | 1.16b(0.86-1.98) | 1.69a(0.76-2.61) | 1.88a(1.19-4.68) | 0.32 (Large) | <0.0001* |
| NFATC3 | 0.94a(0.43-2.78) | 0.57b(0.12-2.1) | 0.81a,b(0.32-2.1) | 1.38a(0.53-2.45) | 0.26 (Large) | <0.0001* |
| EIF5A | 0.25a(-0.17-1.95) | 0.03b(-0.53-0.45) | 0.01b,c(-0.3-0.39) | 0.24a,c(-0.63-1.4) | 0.20 (Large) | <0.0001* |
| EIF4G1 | 7.51a(6.32-8.13) | 2.57b(1.51-5.26) | 4.07c(2.79-4.86) | 4.41c(3.12-6.49) | 0.72 (Large) | <0.0001* |
| CD28 | 1.61a(1.22-4.38) | 1.65a(0.94-3.75) | 1.37a(0.98-1.77) | 1.57a(0.92-2.3) | 0.03 (Large) | 0.130* |
| PTH1R | 3.9a(3.28-5.38) | 4.09a(3.47-4.92) | 3.6a(3.45-4.4) | 3.85a(3.26-4.78) | 0.08 (Large) | 0.019* |
| BIRC2 | 2.13a(1.16-4.28) | 0.31b(-0.01-0.86) | 0.59b,c(0.3-1.01) | 0.71c(0.18-1.58) | 0.70 (Large) | <0.0001* |
| HSD11B1 | 3.1a,b(2.55-3.8) | 3.17a(2.64-4.36) | 2.59b(2.12-3.74) | 2.89b,c(1.96-4.06) | 0.11 (Large) | 0.005* |
| NF2 | 4.01a(2.22-5.11) | 1.72b(-2.48-0.4) | 1.31b(-1.98–0.62) | 1.19b(-2.32-1.56) | 0.63 (Large) | <0.0001* |
| SH2B3 | 6.72a(5.05-8.86) | 2.7b(1.53-6.8) | 3.23b(2.46-3.65) | 2.79b(1.67-5) | 0.59 (Large) | <0.0001* |
| FCRL3 | 1.08a(0.48-1.91) | 0.96a(0.46-1.74) | 0.79a(0.63-2.11) | 0.92a(0.55-1.88) | 0.01 (Moderate) | 0.293* |
| CKAP4 | 4.74a(3.79-5.3) | 4.71a(3.65-5.47) | 5.82b(5.26-7.72) | 6.7c(5.16-9.94) | 0.64 (Large) | <0.0001* |
| JUN | 0.55a(-0.4-5.39) | 0.23a(-0.76-2.76) | 0.2a(-0.57-1.3) | 0.59a(-0.39-3.84) | 0.03 (Large) | 0.121* |
| HEXIM1 | 8.48a(5.94-9.71) | 3.86b(2.64-5.69) | 5.07c(4.51-6.96) | 5.67c(4.68-7.8) | 0.78 (Large) | <0.0001* |
| CLEC4D | 3.36a(2.49-4.54) | 3.49a(2.02-4.47) | 3.82a,b(3.48-5.27) | 4.42b(3.09-7.93) | 0.29 (Large) | <0.0001* |
| PRKCQ | 1.86a(0.8-5.11) | 0.4b(-0.3-1.2) | 0.56b(-0.09-0.93) | 0.57b(0.04-4.82) | 0.57 (Large) | <0.0001* |
| CXADR | 2.22a(1.57-3.45) | 2.18a(1.29-3.3) | 2.5a,b(1.6-3.67) | 2.77b(1.95-4.84) | 0.19 (Large) | <0.0001* |
| IL10 | 3.51a(2.86-6.58) | 3.7a(2.84-7.15) | 5.1b(4.24-6.77) | 5.92b(4.35-7.35) | 0.53 (Large) | <0.0001* |
| SRPK2 | 5.57a(2.85-7.63) | 0.19b(-0.15-1.87) | 1.01b,c(0.41-2.37) | 1.55c(0.74-4.52) | 0.76 (Large) | <0.0001* |
| KLRD1 | 6.44a(5.61-8.36) | 6.62a,b(5.71-7.56) | 7.15a,b(5.98-7.59) | 7.15b(5.83-8.87) | 0.13 (Large) | 0.002* |
| BACH1 | 2.79a(1.46-5.36) | 0.73b(0.22-3.18) | 1.49b,c(1.17-2.98) | 2.12c(1.33-3.79) | 0.61 (Large) | <0.0001* |
| PIK3AP1 | 4.88a(3.49-7.4) | 2.51b(1.32-3.67) | 3.05b,c(2.28-4.72) | 3.18c(1.94-5.86) | 0.54 (Large) | <0.0001* |
| SPRY2 | 7.1a(4.38-9.22) | 1.9b(0.76-7.81) | 2.4b(1.16-2.71) | 2.2b(1.18-5.02) | 0.56 (Large) | <0.0001* |
| STC1 | 5.55a(4.39-6.49) | 7.01b(5.55-7.72) | 7.29b,c(6.65-7.54) | 7.52c(6.43-7.72) | 0.66 (Large) | <0.0001* |
| ARNT | 0.84a,b(0.21-2.32) | 0.36a(-0.3-1.63) | 0.63a,b(0.39-3.91) | 0.83b(-0.07-5.86) | 0.17 (Large) | <0.0001* |
| FAM3B | 4.88a(3.96-5.64) | 4.87a(3.16-5.58) | 4.31b(3.21-4.87) | 4.45a,b(3.34-6.53) | 0.13 (Large) | 0.002* |
| DFFA | 7.31a(5.91-8.94) | 3.8b(2.91-5.09) | 4.61c(4.44-5.93) | 5.24c(4.26-8.38) | 0.73 (Large) | <0.0001* |
| DAPP1 | 9.03a(7.08-9.75) | 2.33b(1.29-5.55) | 2.87b(0.8-3.57) | 2.4b(1.45-5.48) | 0.60 (Large) | <0.0001* |
| PADI2 | 1.41a,c(0.74-2.77) | 0.59b(0.25-3.05) | 0.79a,b(0.52-1.59) | 1.36c(0.51-4.41) | 0.28 (Large) | <0.0001* |
| CLEC7A | 3.33a(-0.07-4.19) | 3.19a(2.1-3.66) | 3.36a(2.88-4.28) | 3.35a(-0.16-6.42) | 0.01 (Moderate) | 0.265* |
| IL12RB1 | 2a(1.57-5.67) | 2.25a(1.73-2.98) | 2.65a,b(2.34-3.33) | 3.05b(2.1-5.01) | 0.46 (Large) | <0.0001* |
| TANK | 3.71a(1.94-5.94) | 1.06b(0.31-2.2) | 1.5b(0.81-2.56) | 1.44b(0.09-4.18) | 0.57 (Large) | <0.0001* |
| KPNA1 | 1.18a(0.05-2.16) | 0.83b(-1.59-0.16) | 0.57b,c(-1.19-1.41) | 0.45c(-1.17-3.03) | 0.57 (Large) | <0.0001* |
| LAG3 | 2.39a(1.79-4.03) | 2.77b(2.2-4.4) | 3.16b,c(2.68-4.04) | 3.28c(2.32-4.64) | 0.34 (Large) | <0.0001* |
| IL5 | 0.63a(0.18-3.5) | 0.55a(0.11-6.91) | 0.9a(0.2-2.99) | 0.66a(0.07-4.38) | 0.01 (Moderate) | 0.259* |
| CD83 | 2.91a(2.41-3.61) | 2.91a(2.17-3.51) | 2.69a(2.36-3.36) | 2.91a(2.18-4.72) | <0.0001 (Small) | 0.397* |
| ITGB6 | 3.07a,b(2.21-3.72) | 2.99a,b(1.85-4.06) | 2.85a(2.2-3.02)a | 3.24b(2.32-5.26)b | 0.08 (Large) | 0.018* |
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |||
| TPSAB1 | 4.81a ± 0.6 | 4.51a ± 0.53 | 4.70a ± 0.59 | 4.46a ± 0.62 | 0.06 (Large) | 0.121⁎⁎ |
| DPP10 | 1.66a ± 0.43 | 1.32b ± 0.35 | 1.02b ± 0.33 | 1.44a,b ± 0.53 | 0.18 (Large) | 0.002⁎⁎ |
| GALNT3 | 2.63a ± 0.46 | 2.99a ± 0.58 | 3.00a ± 0.45 | 3.59b ± 0.56 | 0.35 (Large) | <0.0001⁎⁎ |
| TRIM21 | 5.93a ± 0.63 | 2.52b ± 0.79 | 3.40c ± 0.98 | 4.19c ± 0.93 | 0.75 (Large) | <0.0001⁎⁎ |
| ITM2A | 2.36a ± 0.42 | 2.28a ± 0.95 | 1.84a ± 0.83 | 2.59a ± 1.29 | 0.05 (Large) | 0.202⁎⁎ |
| MILR1 | 2.82a ± 0.46 | 3.16a ± 0.43 | 3.28a,b ± 0.61 | 3.68b ± 0.52 | 0.33 (Large) | <0.0001⁎⁎ |
| LY75 | 3.11a ± 0.35 | 2.86a,c ± 0.45 | 2.42b ± 0.35 | 2.66b,c ± 0.36 | 0.27 (Large) | <0.0001⁎⁎ |
| PLXNA4 | 5.69a ± 0.91 | 3.48b ± 0.82 | 4.14b ± 0.79 | 3.62b ± 0.98b | 0.56 (Large) | <0.0001⁎⁎ |
| MGMT | 7.33a ± 0.59 | 3.34b ± 1.06 | 3.96b,c ± 0.98 | 4.33c ± 0.97 | 0.79 (Large) | <0.0001⁎⁎ |
| TREM1 | 2.36a ± 0.57 | 2.33a ± 0.51 | 3.11b ± 0.49 | 3.20b ± 0.67 | 0.34 (Large) | <0.0001⁎⁎ |
| SH2D1A | 3.23a ± 1.05 | 1.66b ± 0.51 | 1.99b ± 0.5 | 2.15b ± 0.62 | 0.43 (Large) | <0.0001⁎⁎ |
| ICA1 | 3.74a ± 0.91 | 0.78b ± 0.31 | 1.20b,c ± 0.38 | 1.27c ± 0.49 | 0.82 (Large) | <0.0001⁎⁎ |
| DCBLD2 | 7.84a ± 0.36 | 7.96a ± 0.35 | 7.94a ± 0.36 | 7.89a ± 0.44 | 0.02 (Large) | 0.580⁎⁎ |
| FCRL6 | 3.07a ± 0.55 | 3.62b ± 0.65 | 2.97a,b ± 0.56 | 3.46a,b ± 0.77 | 0.14 (Large) | 0.014⁎⁎ |
| NCR1 | 3.48a,b ± 0.41 | 3.27a ± 0.36 | 3.61a,b ± 0.47 | 3.83b ± 0.78 | 0.14 (Large) | 0.004⁎⁎ |
| CXCL12 | 1.55a ± 0.25 | 1.35b ± 0.18 | 1.65a ± 0.27 | 1.72a ± 0.24 | 0.29 (Large) | <0.0001⁎⁎ |
| AREG | 3.39 ± 0.49a | 3.21 ± 0.63a | 4.99 ± 0.77b | 5.78 ± 1.03c | 0.71 (Large) | <0.0001⁎⁎ |
| IFNLR1 | 2.43a ± 0.37 | 2.58a ± 0.28 | 3.02b ± 0.39 | 3.12b ± 0.44 | 0.40 (Large) | <0.0001⁎⁎ |
| SIT1 | 1.79a ± 0.33 | 2.22a ± 0.65 | 3.24b ± 0.99 | 2.93b ± 1.07 | 0.34 (Large) | <0.0001⁎⁎ |
| MASP1 | 2.27a ± 0.33 | 1.96b ± 0.33 | 1.28c ± 0.2 | 1.42c ± 0.28 | 0.62 (Large) | <0.0001⁎⁎ |
| LAMP3 | 4.24a ± 0.61 | 4.68a ± 0.91 | 5.53b ± 0.66 | 6.07b ± 0.47 | 0.56 (Large) | <0.0001⁎⁎ |
| CLEC6A | 1.94a ± 0.56 | 2.26a ± 0.51 | 3.01b ± 0.61 | 3.26b ± 0.65 | 0.49 (Large) | <0.0001⁎⁎ |
| DDX58 | 4.34a ± 0.75 | 2.81b ± 0.82 | 4.09a ± 0.98 | 4.94a ± 1.3 | 0.43 (Large) | <0.0001⁎⁎ |
| ITGA11 | 3.21a ± 0.36 | 2.92a ± 0.42 | 2.12b ± 0.34 | 2.18b ± 0.6 | 0.52 (Large) | <0.0001⁎⁎ |
| BTN3A2 | 3.21a,b ± 0.53 | 2.83a ± 0.39 | 3.39b ± 0.59 | 4.24c ± 0.62 | 0.53 (Large) | <0.0001⁎⁎ |
a, b,c: Different characters in each row show a statistically significant difference (p <0.05)
⁎
Kruskal-Wallis test
⁎⁎
One-way analysis of variance.