Table 3.
Gene annotation of differentially expressed ion channel-related genes in PTE rats.
| gene_name | PTE_FPKM | PN_FPKM | log2 (foldchange) | p-Value | q Value | Gene_description |
|---|---|---|---|---|---|---|
| Kcnn2 | 2.477944667 | 0.00669 | 8.532922046 | 3.76E-05 | 0.014185449 | “Potassium channel domain∥Calmodulin-binding domain∥Potassium channel, calcium-activated, SK” |
| Prom1 | 3.479028333 | 0 | Inf | 1.08E-09 | 2.65E-06 | Prominin |
| Calu | 5.7256 | 0.006981 | 9.679777458 | 0.000111681 | 3.15E-02 | “Calumenin∥EF-hand domain pair∥EF-hand domain∥EF-Hand 1, calcium-binding site” |
| Svep1 | 0.236109 | 0 | Inf | 5.41E-05 | 0.018150161 | “Tyrosine-protein kinase ephrin type A/B receptor-like∥EGF-like, conserved site∥Sushi/SCR/CCP domain∥EGF-type aspartate/asparagine hydroxylation site∥Concanavalin A-like lectin/glucanase domain∥EGF-like domain∥EGF-like calcium-binding domain∥Growth factor receptor cysteine-rich domain∥EGF-like calcium-binding, conserved site∥Pentaxin-related∥von Willebrand factor, type A∥Green fluorescent protein-like∥HYR domain” |
| Chrna6 | 0.993328333 | 0.015922333 | 5.963146987 | 1.17E-05 | 0.005575596 | “Neurotransmitter-gated ion-channel ligand-binding domain∥Neurotransmitter-gated ion-channel, conserved site∥Nicotinic acetylcholine receptor∥Nicotinic acetylcholine-gated receptor, transmembrane domain∥Neurotransmitter-gated ion-channel∥Neurotransmitter-gated ion-channel transmembrane domain” |
| Kcnk15 | 2.198411333 | 0.095449 | 4.525587454 | 3.62E-05 | 0.013831119 | “Two pore domain potassium channel∥Two pore domain potassium channel, TASK family∥Potassium channel domain∥Potassium channel subfamily K member 15” |
| Kcnh2 | 2.334764333 | 0.003191333 | 9.514901914 | 4.44E-09 | 9.52E-06 | “Potassium channel, voltage-dependent, EAG/ELK/ERG∥PAS domain∥RmlC-like jelly roll fold∥Potassium channel, voltage-dependent, ERG∥PAC motif∥Cyclic nucleotide-binding domain∥Ion transport domain∥Cyclic nucleotide-binding-like∥PAS-associated, C-terminal” |
| Camk2b | 4.608144 | 0.536467 | 3.102624467 | 0.000203298 | 0.04531143 | “Calcium/calmodulin-dependent/calcium-dependent protein kinase∥Calcium/calmodulin-dependent protein kinase II, association-domain∥Protein kinase, ATP binding site∥NTF2-like domain∥Protein kinase-like domain∥Protein kinase domain∥Serine/threonine-protein kinase, active site” |
| Nrg1 | 0.534145667 | 0 | Inf | 5.36285E-08 | 8.10241E-05 | “Immunoglobulin I-set∥Neuregulin, C-terminal∥Immunoglobulin subtype 2∥Immunoglobulin-like domain∥Immunoglobulin-like fold∥Immunoglobulin subtype∥Neuregulin-1∥EGF-like, conserved site∥EGF-like domain” |
| Cacna1d | 0.643110333 | 0 | Inf | 3.40E-05 | 0.013308316 | “Voltage-gated calcium channel subunit alpha, C-terminal∥Voltage-dependent channel, four helix bundle domain∥Voltage-dependent L-type calcium channel, IQ-associated domain∥Voltage-dependent calcium channel, alpha-1 subunit∥Voltage-dependent calcium channel, alpha-1 subunit, IQ domain∥Ion transport domain∥Voltage-dependent calcium channel, L-type, alpha-1 subunit∥Voltage-dependent calcium channel, L-type, alpha-1D subunit” |
| Lrguk | 0.561985667 | 0 | Inf | 2.14E-05 | 0.008819948 | “Leucine-rich repeat domain, L domain-like∥P-loop containing nucleoside triphosphate hydrolase∥Guanylate kinase/L-type calcium channel beta subunit∥Guanylate kinase-like domain∥Leucine-rich repeat, typical subtype∥Leucine-rich repeat” |
| Slc24a4 | 0.544000667 | 0 | Inf | 0.000205718 | 0.045344842 | Sodium/potassium/calcium exchanger∥Sodium/potassium/calcium exchanger 4∥Sodium/calcium exchanger membrane region |
| Slc25a22 | 0 | 5.435152333 | #NAME? | 2.98E-06 | 0.001981222 | Mitochondrial carrier domain∥Mitochondrial carrier protein∥Mitochondrial substrate/solute carrier |
| Tshb | 0 | 27.077657 | #NAME? | 0.00020395 | 0.04531143 | “Cystine-knot cytokine∥Glycoprotein hormone subunit beta, cystine knot∥Gonadotropin, beta subunit, conserved site∥Gonadotropin, beta subunit” |
| Ahnak | 0 | 2.561203 | #NAME? | 8.02E-05 | 0.024947173 | PDZ domain |
| Panx1 | 0.002705 | 0.859885 | −8.312371324 | 4.16E-06 | 0.002535909 | -∥Innexin |