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. 2021 Feb 1;7:631398. doi: 10.3389/fcvm.2020.631398

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Copyright © 2021 Ma and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Colchicine affects interleukin 1β/interleukin 6 pathway through NLRP3 inflammasome. Colchicine prevents assembly of NLRP3 inflammasome in cells by inhibiting the function of microtubules, thus reducing the maturation and release of IL-1β and further reducing release of IL-6 from various types of cells.